The first years of school are critical in establishing a foundation for positive long-term academic, social and well-being outcomes. Mindfulness-based interventions may help students transition well into school, but few robust studies have been conducted in this age group.
We aim to determine whether compared with controls, children who receive a mindfulness intervention within the first years of primary school have better: (1) immediate attention/short-term memory at 18 months post-randomisation (primary outcome); (2) inhibition, working memory and cognitive flexibility at 18 months post-randomisation; (3) socio-emotional well-being, emotion-regulation and mental health-related behaviours at 6 and 18 months post-randomisation; (4) sustained changes in teacher practice and classroom interactions at 18 months post-randomisation.
Furthermore, we aim to determine whether the implementation predicts the efficacy of the intervention, and the cost effectiveness relative to outcomes.This cluster randomised controlled trial will be conducted in 22 primary schools in disadvantaged areas of Melbourne, Australia. 826 students in the first year of primary school will be recruited to detect between groups differences of Cohen’s d=0.25 at the 18-month follow-up.
Parent, teacher and child-assessment measures of child attention, emotion-regulation, executive functioning, socio-emotional well-being, mental health-related behaviour and learning, parent mental well-being, teacher well-being will be collected 6 and 18 months post-randomisation.
Human NOP56 Ribonucleoprotein (NOP56) ELISA Kit |
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| abx381849-96tests | Abbexa | 96 tests | 1093.2 EUR |
NOP56 Antibody |
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| 1-CSB-PA384993 | Cusabio |
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Description: A polyclonal antibody against NOP56. Recognizes NOP56 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1:500-2000, ELISA:1:10000-20000 |
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NOP56 siRNA |
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| 20-abx926151 | Abbexa |
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NOP56 siRNA |
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| 20-abx926152 | Abbexa |
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NOP56 Antibody |
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| 1-CSB-PA015939GA01HU | Cusabio |
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Description: A polyclonal antibody against NOP56. Recognizes NOP56 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB |
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NOP56 antibody |
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| 70R-18923 | Fitzgerald | 50 ul | 522 EUR |
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Description: Rabbit polyclonal NOP56 antibody |
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NOP56 Polyclonal Antibody |
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| ABP57510-003ml | Abbkine | 0.03ml | 189.6 EUR |
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Description: A polyclonal antibody for detection of NOP56 from Human, Mouse, Rat. This NOP56 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from NOP56 at AA range: 191-240 |
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NOP56 Polyclonal Antibody |
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| ABP57510-01ml | Abbkine | 0.1ml | 346.8 EUR |
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Description: A polyclonal antibody for detection of NOP56 from Human, Mouse, Rat. This NOP56 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from NOP56 at AA range: 191-240 |
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NOP56 Polyclonal Antibody |
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| ABP57510-02ml | Abbkine | 0.2ml | 496.8 EUR |
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Description: A polyclonal antibody for detection of NOP56 from Human, Mouse, Rat. This NOP56 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from NOP56 at AA range: 191-240 |
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NOP56 Rabbit pAb |
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| A8040-100ul | Abclonal | 100 ul | 460.8 EUR |
NOP56 Rabbit pAb |
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| A8040-200ul | Abclonal | 200 ul | Ask for price |
NOP56 Rabbit pAb |
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| A8040-20ul | Abclonal | 20 ul | Ask for price |
NOP56 Rabbit pAb |
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| A8040-50ul | Abclonal | 50 ul | 318 EUR |
anti- NOP56 antibody |
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| FNab05795 | FN Test | 100µg | 658.5 EUR |
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Description: Antibody raised against NOP56 |
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NOP56 Polyclonal Antibody |
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| ES8503-100ul | ELK Biotech | 100ul | 334.8 EUR |
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Description: A Rabbit Polyclonal antibody against NOP56 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
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NOP56 Polyclonal Antibody |
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| ES8503-50ul | ELK Biotech | 50ul | 248.4 EUR |
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Description: A Rabbit Polyclonal antibody against NOP56 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
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NOP56 Polyclonal Antibody |
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| 46736-100ul | SAB | 100ul | 302.4 EUR |
NOP56 Polyclonal Antibody |
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| 46736-50ul | SAB | 50ul | 224.4 EUR |
Anti-NOP56 Antibody |
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| A04335 | BosterBio | 100ul | 476.4 EUR |
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Description: Rabbit Polyclonal Antibody for NOP56 Antibody (NOP56) detection.tested for IHC, WB in Human, Mouse, Rat. |
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Anti-NOP56 antibody |
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| PAab05795 | Lifescience Market | 100 ug | 463.2 EUR |
Anti-NOP56 antibody |
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| STJ110344 | St John's Laboratory | 100 µl | 471.6 EUR |
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Description: Nop56p is a yeast nucleolar protein that is part of a complex with the nucleolar proteins Nop58p and fibrillarin. Nop56p is required for assembly of the 60S ribosomal subunit and is involved in pre-rRNA processing. The protein encoded by this gene is similar in sequence to Nop56p and is also found in the nucleolus. Expansion of a GGCCTG repeat from 3-8 copies to 1500-2500 copies in an intron of this gene results in spinocerebellar ataxia 36. Multiple transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of most of them has not been determined. |
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Anti-NOP56 antibody |
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| STJ98616 | St John's Laboratory | 200 µl | 236.4 EUR |
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Description: Rabbit polyclonal to NOP56. |
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Human NOP56 shRNA Plasmid |
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| 20-abx957155 | Abbexa |
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Mouse NOP56 shRNA Plasmid |
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| 20-abx975991 | Abbexa |
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NOP56 ELISA KIT|Human |
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| EF001286 | Lifescience Market | 96 Tests | 826.8 EUR |
NOP56 Recombinant Protein (Human) |
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| RP021469 | ABM | 100 ug | Ask for price |
NOP56 Recombinant Protein (Rat) |
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| RP214226 | ABM | 100 ug | Ask for price |
NOP56 Recombinant Protein (Mouse) |
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| RP154574 | ABM | 100 ug | Ask for price |
Nop56 ORF Vector (Rat) (pORF) |
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| ORF071410 | ABM | 1.0 ug DNA | 607.2 EUR |
NOP56 ORF Vector (Human) (pORF) |
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| ORF007157 | ABM | 1.0 ug DNA | 114 EUR |
Nop56 ORF Vector (Mouse) (pORF) |
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| ORF051526 | ABM | 1.0 ug DNA | 607.2 EUR |
NOP56 sgRNA CRISPR Lentivector set (Human) |
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| K1440801 | ABM | 3 x 1.0 ug | 406.8 EUR |
Nop56 sgRNA CRISPR Lentivector set (Rat) |
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| K7169201 | ABM | 3 x 1.0 ug | 406.8 EUR |
Nop56 sgRNA CRISPR Lentivector set (Mouse) |
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| K4919601 | ABM | 3 x 1.0 ug | 406.8 EUR |
Mouse Nucleolar protein 56, Nop56 ELISA KIT |
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| ELI-46118m | Lifescience Market | 96 Tests | 1038 EUR |
Human Nucleolar protein 56, NOP56 ELISA KIT |
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| ELI-35313h | Lifescience Market | 96 Tests | 988.8 EUR |
NOP56 sgRNA CRISPR Lentivector (Human) (Target 1) |
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| K1440802 | ABM | 1.0 ug DNA | 184.8 EUR |
NOP56 sgRNA CRISPR Lentivector (Human) (Target 2) |
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| K1440803 | ABM | 1.0 ug DNA | 184.8 EUR |
NOP56 sgRNA CRISPR Lentivector (Human) (Target 3) |
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| K1440804 | ABM | 1.0 ug DNA | 184.8 EUR |
Bovine Nucleolar protein 56, NOP56 ELISA KIT |
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| ELI-16702b | Lifescience Market | 96 Tests | 1113.6 EUR |
Nop56 sgRNA CRISPR Lentivector (Rat) (Target 1) |
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| K7169202 | ABM | 1.0 ug DNA | 184.8 EUR |
Nop56 sgRNA CRISPR Lentivector (Rat) (Target 2) |
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| K7169203 | ABM | 1.0 ug DNA | 184.8 EUR |
Nop56 sgRNA CRISPR Lentivector (Rat) (Target 3) |
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| K7169204 | ABM | 1.0 ug DNA | 184.8 EUR |
Nop56 sgRNA CRISPR Lentivector (Mouse) (Target 1) |
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| K4919602 | ABM | 1.0 ug DNA | 184.8 EUR |
Nop56 sgRNA CRISPR Lentivector (Mouse) (Target 2) |
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| K4919603 | ABM | 1.0 ug DNA | 184.8 EUR |
Nop56 sgRNA CRISPR Lentivector (Mouse) (Target 3) |
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| K4919604 | ABM | 1.0 ug DNA | 184.8 EUR |
NOP56 Protein Vector (Human) (pPB-C-His) |
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| PV028625 | ABM | 500 ng | 394.8 EUR |
NOP56 Protein Vector (Human) (pPB-N-His) |
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| PV028626 | ABM | 500 ng | 394.8 EUR |
NOP56 Protein Vector (Human) (pPM-C-HA) |
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| PV028627 | ABM | 500 ng | 394.8 EUR |
NOP56 Protein Vector (Human) (pPM-C-His) |
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| PV028628 | ABM | 500 ng | 394.8 EUR |
NOP56 Protein Vector (Rat) (pPB-C-His) |
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| PV285638 | ABM | 500 ng | 723.6 EUR |
NOP56 Protein Vector (Rat) (pPB-N-His) |
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| PV285639 | ABM | 500 ng | 723.6 EUR |
NOP56 Protein Vector (Rat) (pPM-C-HA) |
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| PV285640 | ABM | 500 ng | 723.6 EUR |
NOP56 Protein Vector (Rat) (pPM-C-His) |
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| PV285641 | ABM | 500 ng | 723.6 EUR |
NOP56 Protein Vector (Mouse) (pPB-C-His) |
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| PV206102 | ABM | 500 ng | 723.6 EUR |
NOP56 Protein Vector (Mouse) (pPB-N-His) |
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| PV206103 | ABM | 500 ng | 723.6 EUR |
NOP56 Protein Vector (Mouse) (pPM-C-HA) |
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| PV206104 | ABM | 500 ng | 723.6 EUR |
NOP56 Protein Vector (Mouse) (pPM-C-His) |
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| PV206105 | ABM | 500 ng | 723.6 EUR |
Nop56 3'UTR Luciferase Stable Cell Line |
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| TU214084 | ABM | 1.0 ml | Ask for price |
Nop56 3'UTR GFP Stable Cell Line |
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| TU264084 | ABM | 1.0 ml | Ask for price |
Nop56 3'UTR Luciferase Stable Cell Line |
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| TU114211 | ABM | 1.0 ml | Ask for price |
Nop56 3'UTR GFP Stable Cell Line |
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| TU164211 | ABM | 1.0 ml | Ask for price |
NOP56 3'UTR GFP Stable Cell Line |
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| TU065823 | ABM | 1.0 ml | 1672.8 EUR |
NOP56 3'UTR Luciferase Stable Cell Line |
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| TU015823 | ABM | 1.0 ml | 1672.8 EUR |
NOP56 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV) |
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| LV628063 | ABM | 1.0 ug DNA | 818.4 EUR |
NOP56 Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC) |
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| LV628067 | ABM | 1.0 ug DNA | 818.4 EUR |
NOP56 Lentiviral Vector (Rat) (EF1a) (pLenti-GIII-EF1a) |
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| LV628068 | ABM | 1.0 ug DNA | 818.4 EUR |
NOP56 Lentiviral Vector (Human) (UbC) (pLenti-GIII-UbC) |
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| LV792199 | ABM | 1.0 ug DNA | 379.2 EUR |
NOP56 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
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| LV792200 | ABM | 1.0 ug DNA | 379.2 EUR |
NOP56 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human) |
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| K1440805 | ABM | 3 x 1.0 ug | 451.2 EUR |
Nop56 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Rat) |
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| K7169205 | ABM | 3 x 1.0 ug | 451.2 EUR |
Nop56 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse) |
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| K4919605 | ABM | 3 x 1.0 ug | 451.2 EUR |
NOP56 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-C-term-HA) |
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| LV628064 | ABM | 1.0 ug DNA | 818.4 EUR |
NOP56 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro) |
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| LV628065 | ABM | 1.0 ug DNA | 888 EUR |
NOP56 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro) |
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| LV628066 | ABM | 1.0 ug DNA | 888 EUR |
NOP56 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1) |
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| K1440806 | ABM | 1.0 ug DNA | 200.4 EUR |
NOP56 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2) |
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| K1440807 | ABM | 1.0 ug DNA | 200.4 EUR |
NOP56 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3) |
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| K1440808 | ABM | 1.0 ug DNA | 200.4 EUR |
Nop56 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 1) |
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| K7169206 | ABM | 1.0 ug DNA | 200.4 EUR |
Nop56 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 2) |
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| K7169207 | ABM | 1.0 ug DNA | 200.4 EUR |
Nop56 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 3) |
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| K7169208 | ABM | 1.0 ug DNA | 200.4 EUR |
Nop56 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 1) |
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| K4919606 | ABM | 1.0 ug DNA | 200.4 EUR |
Nop56 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2) |
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| K4919607 | ABM | 1.0 ug DNA | 200.4 EUR |
Nop56 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 3) |
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| K4919608 | ABM | 1.0 ug DNA | 200.4 EUR |
Implementation factors will be measured throughout the study. Intention-to-treat analyses, accounting for clustering within schools and classes, will adopt a two-level random effects linear regression model to examine outcomes for the intervention versus control students. Unadjusted and analyses adjusted for baseline scores, baseline age, gender and family socioeconomic status will be conducted.
Ethics approval has been received by the Human Research Ethics Committee at the University of Melbourne. Findings will be reported in peer-review publications, national and international conference presentations and research snapshots directly provided to participating schools and families.