Clinical guidelines and systematic reviews recommend exercise in the management of chronic non-specific neck pain. Although exercise training programmes that consist of both motor control exercise and exercises for the superficial cervical muscles (segmental exercises) are effective, the exercise variables including dosage vary considerably across trials or are poorly reported.
This study aims to gain expert consensus on these exercise variables so that they can be described clearly using intervention reporting checklists to inform clinical practice and future clinical trials.This protocol for an international Delphi study is informed by the Guidance on Conducting and REporting DElphi Studies recommendations and published to ensure quality, rigour and transparency.
The study will consist of three rounds using anonymous online questionnaires. Expert exercise professionals (physiotherapists, strength and conditioning coaches and so on) and academics in neck pain management will be identified through literature searches, peer referral and social media calls for expression of interest. In round 1, participants will answer open-ended questions informed by intervention and exercise reporting checklists. Responses will be analysed thematically by two independent reviewers.
In round 2, participants will rate their level of agreement with statements generated from round 1 and previous clinical trials using a 5-point Likert scale where 1=strongly disagree and 5=strongly agree. In round 3, participants will re-rate their agreement with statements that achieved consensus in round 2. Statements reaching consensus among participants must meet progressively increased a priori criteria at rounds 2 and 3, measured using descriptive statistics: median, IQR and percentage agreement.
NOP58 (GFP-tagged) - Human NOP58 ribonucleoprotein homolog (yeast) (NOP58) |
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| RG207514 | Origene Technologies GmbH | 10 µg | Ask for price |
Nop58 (Myc-DDK-tagged) - Mouse NOP58 ribonucleoprotein homolog (yeast) (Nop58) |
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| MR207552 | Origene Technologies GmbH | 10 µg | Ask for price |
NOP58 (Myc-DDK-tagged)-Human NOP58 ribonucleoprotein homolog (yeast) (NOP58) |
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| RC207514 | Origene Technologies GmbH | 10 µg | Ask for price |
Human NOP58 Ribonucleoprotein (NOP58) ELISA Kit |
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| abx381850-96tests | Abbexa | 96 tests | 1093.2 EUR |
Nop58 Ribonucleoprotein Homolog (Yeast) (NOP58) Antibody |
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| 20-abx114154 | Abbexa |
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NOP58 siRNA |
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| 20-abx926153 | Abbexa |
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NOP58 siRNA |
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| 20-abx926154 | Abbexa |
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NOP58 siRNA |
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| 20-abx903599 | Abbexa |
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NOP58 Antibody |
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| 1-CSB-PA896703LA01HU | Cusabio |
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Description: A polyclonal antibody against NOP58. Recognizes NOP58 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF; Recommended dilution: WB:1:500-1:5000, IF:1:50-1:200 |
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NOP58 Antibody |
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| 1-CSB-PA015940GA01HU | Cusabio |
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Description: A polyclonal antibody against NOP58. Recognizes NOP58 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB |
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NOP58 Antibody |
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| DF13192 | Affbiotech | 200ul | 420 EUR |
NOP58 Antibody |
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| DF13192-100ul | Affinity Biosciences | 100ul | 280 EUR |
NOP58 Antibody |
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| DF13192-200ul | Affinity Biosciences | 200ul | 350 EUR |
NOP58 antibody |
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| E39-10461 | EnoGene | 100ug/100ul | 225 EUR |
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Description: Available in various conjugation types. |
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NOP58 Antibody |
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| E94749 | EnoGene | 100μg | 255 EUR |
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Description: Available in various conjugation types. |
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NOP58 Antibody |
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| E308307 | EnoGene | 200ul | 275 EUR |
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Description: Available in various conjugation types. |
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NOP58 Antibody |
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| CAC09967-100ug | Biomatik Corporation | 100ug | 314 EUR |
NOP58 Antibody |
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| CAC09967-50ug | Biomatik Corporation | 50ug | 199.2 EUR |
NOP58 antibody |
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| 70R-18924 | Fitzgerald | 50 ul | 289 EUR |
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Description: Rabbit polyclonal NOP58 antibody |
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NOP58 Antibody |
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| MBS8502854-01mg | MyBiosource | 0.1mg | 325 EUR |
NOP58 Antibody |
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| MBS8502854-01mLAF405L | MyBiosource | 0.1mL(AF405L) | 565 EUR |
NOP58 Antibody |
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| MBS8502854-01mLAF405S | MyBiosource | 0.1mL(AF405S) | 565 EUR |
NOP58 Antibody |
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| MBS8502854-01mLAF610 | MyBiosource | 0.1mL(AF610) | 565 EUR |
NOP58 Antibody |
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| MBS8502854-01mLAF635 | MyBiosource | 0.1mL(AF635) | 565 EUR |
NOP58 Antibody |
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| MBS9611942-01mL | MyBiosource | 0.1mL | 260 EUR |
NOP58 Antibody |
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| MBS9611942-02mL | MyBiosource | 0.2mL | 305 EUR |
NOP58 Antibody |
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| MBS9611942-5x02mL | MyBiosource | 5x0.2mL | 1220 EUR |
Lenti ORF clone of Nop58 (mGFP-tagged) - Mouse NOP58 ribonucleoprotein homolog (yeast) (Nop58) |
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| MR207552L4 | Origene Technologies GmbH | 10 µg | Ask for price |
NOP5/NOP58 antibody |
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| 70R-3412 | Fitzgerald | 50 ug | 467 EUR |
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Description: Rabbit polyclonal NOP5/NOP58 antibody raised against the middle region of NOP5/NOP58 |
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NOP5/NOP58 antibody |
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| MBS5300983-01mL | MyBiosource | 0.1mL | 750 EUR |
NOP5/NOP58 antibody |
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| MBS5300983-5x01mL | MyBiosource | 5x0.1mL | 3215 EUR |
Lenti ORF clone of Nop58 (Myc-DDK-tagged) - Mouse NOP58 ribonucleoprotein homolog (yeast) (Nop58) |
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| MR207552L3 | Origene Technologies GmbH | 10 µg | Ask for price |
NOP58 siRNA (Rat) |
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| MBS8224208-15nmol | MyBiosource | 15nmol | 405 EUR |
NOP58 siRNA (Rat) |
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| MBS8224208-30nmol | MyBiosource | 30nmol | 565 EUR |
NOP58 siRNA (Rat) |
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| MBS8224208-5x30nmol | MyBiosource | 5x30nmol | 2450 EUR |
NOP58 Rabbit pAb |
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| E2504749 | EnoGene | 100ul | 225 EUR |
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Description: Available in various conjugation types. |
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NOP58 Rabbit pAb |
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| E2514129 | EnoGene | 100ul | 225 EUR |
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Description: Available in various conjugation types. |
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NOP58 Rabbit pAb |
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| A4749-100ul | Abclonal | 100 ul | 369.6 EUR |
NOP58 Rabbit pAb |
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| A4749-200ul | Abclonal | 200 ul | 550.8 EUR |
NOP58 Rabbit pAb |
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| A4749-20ul | Abclonal | 20 ul | 219.6 EUR |
NOP58 Rabbit pAb |
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| A4749-50ul | Abclonal | 50 ul | 267.6 EUR |
NOP58 Rabbit pAb |
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| A14129-100ul | Abclonal | 100 ul | 369.6 EUR |
NOP58 Rabbit pAb |
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| A14129-200ul | Abclonal | 200 ul | 550.8 EUR |
NOP58 Rabbit pAb |
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| A14129-20ul | Abclonal | 20 ul | 219.6 EUR |
NOP58 Rabbit pAb |
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| A14129-50ul | Abclonal | 50 ul | 267.6 EUR |
NOP58 Rabbit pAb |
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| E2127378 | EnoGene | 100ul | 225 EUR |
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Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
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NOP58 Rabbit pAb |
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| E2827378 | EnoGene | 100ul | 225 EUR |
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Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
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NOP58 Rabbit pAb |
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| MBS8549354-01mL | MyBiosource | 0.1mL | 305 EUR |
NOP58 Rabbit pAb |
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| MBS8549354-01mLAF405L | MyBiosource | 0.1mL(AF405L) | 565 EUR |
NOP58 Rabbit pAb |
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| MBS8549354-01mLAF405S | MyBiosource | 0.1mL(AF405S) | 565 EUR |
NOP58 Rabbit pAb |
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| MBS8549354-01mLAF610 | MyBiosource | 0.1mL(AF610) | 565 EUR |
NOP58 Rabbit pAb |
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| MBS8549354-01mLAF635 | MyBiosource | 0.1mL(AF635) | 565 EUR |
NOP58 Rabbit pAb |
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| MBS8545427-01mL | MyBiosource | 0.1mL | 305 EUR |
NOP58 Rabbit pAb |
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| MBS8545427-01mLAF405L | MyBiosource | 0.1mL(AF405L) | 565 EUR |
NOP58 Rabbit pAb |
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| MBS8545427-01mLAF405S | MyBiosource | 0.1mL(AF405S) | 565 EUR |
NOP58 Rabbit pAb |
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| MBS8545427-01mLAF610 | MyBiosource | 0.1mL(AF610) | 565 EUR |
NOP58 Rabbit pAb |
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| MBS8545427-01mLAF635 | MyBiosource | 0.1mL(AF635) | 565 EUR |
NOP58 Rabbit pAb |
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| A14129 | Abclonal | 20μL | 88.56 EUR |
NOP58 Rabbit pAb |
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| A4749 | Abclonal | 500μL | 262.15 EUR |
NOP58 siRNA (Human) |
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| MBS8236011-15nmol | MyBiosource | 15nmol | 405 EUR |
NOP58 siRNA (Human) |
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| MBS8236011-30nmol | MyBiosource | 30nmol | 565 EUR |
NOP58 siRNA (Human) |
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| MBS8236011-5x30nmol | MyBiosource | 5x30nmol | 2450 EUR |
NOP58 siRNA (Mouse) |
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| MBS8205978-15nmol | MyBiosource | 15nmol | 405 EUR |
NOP58 siRNA (Mouse) |
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| MBS8205978-30nmol | MyBiosource | 30nmol | 565 EUR |
NOP58 siRNA (Mouse) |
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| MBS8205978-5x30nmol | MyBiosource | 5x30nmol | 2450 EUR |
anti- NOP58 antibody |
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| FNab05796 | FN Test | 100µg | 606.3 EUR |
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Description: Antibody raised against NOP58 |
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NOP58 Blocking Peptide |
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| DF13192-BP | Affbiotech | 1mg | 234 EUR |
NOP58 Blocking Peptide |
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| MBS9621895-1mg | MyBiosource | 1mg | 380 EUR |
NOP58 Blocking Peptide |
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| MBS9621895-5x1mg | MyBiosource | 5x1mg | 1650 EUR |
Recombinant Human NOP58 |
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| MBS7613637-005mg | MyBiosource | 0.05mg | 345 EUR |
Recombinant Human NOP58 |
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| MBS7613637-02mg | MyBiosource | 0.2mg | 635 EUR |
Recombinant Human NOP58 |
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| MBS7613637-1mg | MyBiosource | 1mg | 1800 EUR |
Recombinant Human NOP58 |
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| MBS7613637-5x1mg | MyBiosource | 5x1mg | 6955 EUR |
NOP58 Polyclonal Antibody |
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| 28438 | SAB | 100ul | 439 EUR |
NOP58 Polyclonal Antibody |
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| 28438-100ul | SAB | 100ul | 302.4 EUR |
NOP58 Polyclonal Antibody |
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| 28438-50ul | SAB | 50ul | 224.4 EUR |
NOP58 Polyclonal Antibody |
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| 30604 | SAB | 100ul | 439 EUR |
NOP58 Polyclonal Antibody |
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| 30604-100ul | SAB | 100ul | 302.4 EUR |
NOP58 Polyclonal Antibody |
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| 30604-50ul | SAB | 50ul | 224.4 EUR |
NOP58 Polyclonal Antibody |
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| E914129 | EnoGene | 100ul | 225 EUR |
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Description: Available in various conjugation types. |
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NOP58 Polyclonal Antibody |
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| A54768 | EpiGentek |
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NOP58 Polyclonal Antibody |
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| MBS128763-002mL | MyBiosource | 0.02mL | 200 EUR |
NOP58 Polyclonal Antibody |
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| MBS128763-005mL | MyBiosource | 0.05mL | 255 EUR |
NOP58 Polyclonal Antibody |
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| MBS128763-01mL | MyBiosource | 0.1mL | 345 EUR |
NOP58 Polyclonal Antibody |
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| MBS128763-02mL | MyBiosource | 0.2mL | 545 EUR |
NOP58 Polyclonal Antibody |
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| MBS128763-5x02mL | MyBiosource | 5x0.2mL | 2265 EUR |
NOP58 Polyclonal Antibody |
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| A71472 | EpiGentek | 50 μl | 408 EUR |
NOP58 Polyclonal Antibody |
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| E-AB-64937-120uL | Elabscience Biotech | 120uL | 320 EUR |
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Description: Unconjugated |
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NOP58 Polyclonal Antibody |
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| E-AB-64937-200uL | Elabscience Biotech | 200uL | 530 EUR |
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Description: Unconjugated |
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NOP58 Polyclonal Antibody |
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| E-AB-64937-60uL | Elabscience Biotech | 60uL | 200 EUR |
|
Description: Unconjugated |
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NOP58 Polyclonal Antibody |
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| E-AB-64937-each | Elabscience Biotech | each | Ask for price |
|
Description: Unconjugated |
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NOP58 Polyclonal Antibody |
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| E-AB-62449-120uL | Elabscience Biotech | 120uL | 320 EUR |
|
Description: Unconjugated |
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NOP58 Polyclonal Antibody |
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| E-AB-62449-200uL | Elabscience Biotech | 200uL | 530 EUR |
|
Description: Unconjugated |
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NOP58 Polyclonal Antibody |
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| E-AB-62449-60uL | Elabscience Biotech | 60uL | 200 EUR |
|
Description: Unconjugated |
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NOP58 Polyclonal Antibody |
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| E-AB-62449-each | Elabscience Biotech | each | Ask for price |
|
Description: Unconjugated |
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NOP58 Polyclonal Antibody |
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| MBS9134139-002mL | MyBiosource | 0.02mL | 200 EUR |
NOP58 Polyclonal Antibody |
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| MBS9134139-005mL | MyBiosource | 0.05mL | 255 EUR |
NOP58 Polyclonal Antibody |
|||
| MBS9134139-01mL | MyBiosource | 0.1mL | 345 EUR |
NOP58 Polyclonal Antibody |
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| MBS9134139-02mL | MyBiosource | 0.2mL | 545 EUR |
NOP58 Polyclonal Antibody |
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| MBS9134139-5x02mL | MyBiosource | 5x0.2mL | 2265 EUR |
NOP58 Polyclonal Antibody |
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| MBS8568825-01mL | MyBiosource | 0.1mL | 305 EUR |
NOP58 Polyclonal Antibody |
|||
| MBS8568825-01mLAF405L | MyBiosource | 0.1mL(AF405L) | 565 EUR |
NOP58 Polyclonal Antibody |
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| MBS8568825-01mLAF405S | MyBiosource | 0.1mL(AF405S) | 565 EUR |
NOP58 Polyclonal Antibody |
|||
| MBS8568825-01mLAF610 | MyBiosource | 0.1mL(AF610) | 565 EUR |
NOP58 Polyclonal Antibody |
|||
| MBS8568825-01mLAF635 | MyBiosource | 0.1mL(AF635) | 565 EUR |
NOP58 Polyclonal Antibody |
|||
| MBS2540981-006mL | MyBiosource | 0.06mL | 190 EUR |
NOP58 Polyclonal Antibody |
|||
| MBS2540981-012mL | MyBiosource | 0.12mL | 265 EUR |
NOP58 Polyclonal Antibody |
|||
| MBS2540981-02mL | MyBiosource | 0.2mL | 415 EUR |
NOP58 Polyclonal Antibody |
|||
| MBS2540981-5x02mL | MyBiosource | 5x0.2mL | 1835 EUR |
NOP58 Polyclonal Antibody |
|||
| MBS2555312-006mL | MyBiosource | 0.06mL | 190 EUR |
NOP58 Polyclonal Antibody |
|||
| MBS2555312-012mL | MyBiosource | 0.12mL | 265 EUR |
NOP58 Polyclonal Antibody |
|||
| MBS2555312-02mL | MyBiosource | 0.2mL | 415 EUR |
NOP58 Polyclonal Antibody |
|||
| MBS2555312-5x02mL | MyBiosource | 5x0.2mL | 1835 EUR |
NOP58 Polyclonal Antibody |
|||
| MBS9433735-005mL | MyBiosource | 0.05mL | 300 EUR |
NOP58 Polyclonal Antibody |
|||
| MBS9433735-01mL | MyBiosource | 0.1mL | 390 EUR |
NOP58 Polyclonal Antibody |
|||
| MBS9433735-5x01mL | MyBiosource | 5x0.1mL | 1610 EUR |
NOP58 Polyclonal Antibody |
|||
| MBS9432032-005mL | MyBiosource | 0.05mL | 300 EUR |
NOP58 Polyclonal Antibody |
|||
| MBS9432032-01mL | MyBiosource | 0.1mL | 390 EUR |
NOP58 Polyclonal Antibody |
|||
| MBS9432032-5x01mL | MyBiosource | 5x0.1mL | 1610 EUR |
NOP58 Polyclonal Antibody |
|||
| RD81721A-120uL | Reddot Biotech | 120μL | 360 EUR |
|
Description: The protein encoded by this gene is a core component of box C/D small nucleolar ribonucleoproteins. Some box C/D small nucleolar RNAs (snoRNAs), such as U3, U8, and U14, are dependent upon the encoded protein for their synthesis. This protein is SUMOylated, which is necessary for high affinity binding to snoRNAs. |
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Inferential statistics will be used to evaluate measures of agreement between participants (Kendall’s coefficient of concordance) and stability between rounds (Wilcoxon rank-sum test). Statements achieving consensus in round 3 will provide expert recommendations of the key exercise and dosage variables in the management of chronic non-specific neck pain.Ethical approval was provided by the University of Birmingham Ethics Committee (Ref:ERN_19-1857). Results will be disseminated through peer-reviewed publications and conference presentations.