Consensus on the exercise and dosage variables of an exercise training programme for chronic non-specific neck pain: protocol for an international e-Delphi study.

Clinical guidelines and systematic reviews recommend exercise in the management of chronic non-specific neck pain. Although exercise training programmes that consist of both motor control exercise and exercises for the superficial cervical muscles (segmental exercises) are effective, the exercise variables including dosage vary considerably across trials or are poorly reported.

This study aims to gain expert consensus on these exercise variables so that they can be described clearly using intervention reporting checklists to inform clinical practice and future clinical trials.This protocol for an international Delphi study is informed by the Guidance on Conducting and REporting DElphi Studies recommendations and published to ensure quality, rigour and transparency.

The study will consist of three rounds using anonymous online questionnaires. Expert exercise professionals (physiotherapists, strength and conditioning coaches and so on) and academics in neck pain management will be identified through literature searches, peer referral and social media calls for expression of interest. In round 1, participants will answer open-ended questions informed by intervention and exercise reporting checklists. Responses will be analysed thematically by two independent reviewers.

In round 2, participants will rate their level of agreement with statements generated from round 1 and previous clinical trials using a 5-point Likert scale where 1=strongly disagree and 5=strongly agree. In round 3, participants will re-rate their agreement with statements that achieved consensus in round 2. Statements reaching consensus among participants must meet progressively increased a priori criteria at rounds 2 and 3, measured using descriptive statistics: median, IQR and percentage agreement.

Nop58 (untagged) - Mouse NOP58 ribonucleoprotein homolog (yeast) (Nop58), (10ug)

MC203524 Origene Technologies GmbH 10 µg Ask for price

NOP58 (GFP-tagged) - Human NOP58 ribonucleoprotein homolog (yeast) (NOP58)

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NOP58 (Myc-DDK-tagged)-Human NOP58 ribonucleoprotein homolog (yeast) (NOP58)

RC207514 Origene Technologies GmbH 10 µg Ask for price

Nop58 (Myc-DDK-tagged) - Mouse NOP58 ribonucleoprotein homolog (yeast) (Nop58)

MR207552 Origene Technologies GmbH 10 µg Ask for price

Human NOP58 Ribonucleoprotein (NOP58) ELISA Kit

abx381850-96tests Abbexa 96 tests 1093.2 EUR

Nop58 Ribonucleoprotein Homolog (Yeast) (NOP58) Antibody

20-abx114154 Abbexa
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NOP58 siRNA

20-abx926153 Abbexa
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NOP58 siRNA

20-abx926154 Abbexa
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  • 15 nmol
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NOP58 siRNA

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  • 15 nmol
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NOP58 Antibody

1-CSB-PA015940GA01HU Cusabio
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  • 150ul
  • 50ul
Description: A polyclonal antibody against NOP58. Recognizes NOP58 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB

NOP58 Antibody

E94749 EnoGene 100μg 255 EUR
Description: Available in various conjugation types.

NOP58 Antibody

DF13192 Affbiotech 200ul 420 EUR

NOP58 Antibody

DF13192-100ul Affinity Biosciences 100ul 280 EUR

NOP58 Antibody

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NOP58 antibody

E39-10461 EnoGene 100ug/100ul 225 EUR
Description: Available in various conjugation types.

NOP58 Antibody

E308307 EnoGene 200ul 275 EUR
Description: Available in various conjugation types.

NOP58 antibody

70R-18924 Fitzgerald 50 ul 289 EUR
Description: Rabbit polyclonal NOP58 antibody

NOP58 Antibody

CAC09967-100ug Biomatik Corporation 100ug 314 EUR

NOP58 Antibody

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NOP58 Antibody

1-CSB-PA896703LA01HU Cusabio
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Description: A polyclonal antibody against NOP58. Recognizes NOP58 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF; Recommended dilution: WB:1:500-1:5000, IF:1:50-1:200

Lenti ORF clone of Nop58 (mGFP-tagged) - Mouse NOP58 ribonucleoprotein homolog (yeast) (Nop58)

MR207552L4 Origene Technologies GmbH 10 µg Ask for price

NOP5/NOP58 antibody

70R-3412 Fitzgerald 50 ug 467 EUR
Description: Rabbit polyclonal NOP5/NOP58 antibody raised against the middle region of NOP5/NOP58

Lenti ORF clone of Nop58 (Myc-DDK-tagged) - Mouse NOP58 ribonucleoprotein homolog (yeast) (Nop58)

MR207552L3 Origene Technologies GmbH 10 µg Ask for price

NOP58 Rabbit pAb

E2514129 EnoGene 100ul 225 EUR
Description: Available in various conjugation types.

NOP58 Rabbit pAb

E2504749 EnoGene 100ul 225 EUR
Description: Available in various conjugation types.

NOP58 Rabbit pAb

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NOP58 Rabbit pAb

E2827378 EnoGene 100ul 225 EUR
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

NOP58 Rabbit pAb

E2127378 EnoGene 100ul 225 EUR
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

anti- NOP58 antibody

FNab05796 FN Test 100µg 606.3 EUR
Description: Antibody raised against NOP58

NOP58 Blocking Peptide

DF13192-BP Affbiotech 1mg 234 EUR

NOP58 Polyclonal Antibody

28438 SAB 100ul 439 EUR

NOP58 Polyclonal Antibody

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NOP58 Polyclonal Antibody

30604-50ul SAB 50ul 224.4 EUR

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Description: Available in various conjugation types.

NOP58 Polyclonal Antibody

A54768 EpiGentek
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NOP58 Polyclonal Antibody

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NOP5/NOP58 Blocking Peptide

33R-5398 Fitzgerald 100 ug 119 EUR
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of NOP5/NOP58 antibody, catalog no. 70R-3412

Lenti ORF particles, Nop58 (GFP-tagged) - Mouse NOP58 ribonucleoprotein homolog (yeast) (Nop58), 200ul, >10^7 TU/mL

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Lenti ORF particles, NOP58 (Myc-DDK tagged) - Human NOP58 ribonucleoprotein homolog (yeast) (NOP58), 200ul, >10^7 TU/mL

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Lenti ORF particles, Nop58 (Myc-DDK-tagged) - Mouse NOP58 ribonucleoprotein homolog (yeast) (Nop58), 200ul, >10^7 TU/mL

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Rat NOP58 shRNA Plasmid

20-abx986026 Abbexa
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Human NOP58 shRNA Plasmid

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NOP58 Antibody, HRP conjugated

1-CSB-PA896703LB01HU Cusabio
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  • 100ug
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Description: A polyclonal antibody against NOP58. Recognizes NOP58 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

NOP58 Recombinant Protein (Rat)

RP214229 ABM 100 ug Ask for price

NOP58 Antibody, FITC conjugated

1-CSB-PA896703LC01HU Cusabio
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  • 100ug
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Description: A polyclonal antibody against NOP58. Recognizes NOP58 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

NOP58 Recombinant Protein (Mouse)

RP154577 ABM 100 ug Ask for price

OACA06524-50UG - NOP58 Antibody

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NOP58 Antibody, Biotin conjugated

1-CSB-PA896703LD01HU Cusabio
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Description: A polyclonal antibody against NOP58. Recognizes NOP58 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

OACA06524-100UG - NOP58 Antibody

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NOP58 Rabbit Polyclonal Antibody

E10G03552 EnoGene 100 μl 275 EUR
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

NOP58 Rabbit Polyclonal Antibody

E10G10558 EnoGene 100 μl 275 EUR
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

NOP58 Polyclonal Conjugated Antibody

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Lenti ORF clone of Human NOP58 ribonucleoprotein homolog (yeast) (NOP58), mGFP tagged

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Nop58 ORF Vector (Rat) (pORF)

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NOP58 ORF Vector (Human) (pORF)

ORF007158 ABM 1.0 ug DNA 114 EUR

Nop58 ORF Vector (Mouse) (pORF)

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Lenti ORF clone of Human NOP58 ribonucleoprotein homolog (yeast) (NOP58), Myc-DDK-tagged

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3`UTR clone of NOP58 ribonucleoprotein homolog (yeast) (NOP58) for miRNA target validation

SC202891 Origene Technologies GmbH 10 µg Ask for price

Human NOP58 Protein Lysate 20ug

IHUNOP58PLLY20UG Innovative research each 213 EUR
Description: Human NOP58 Protein Lysate 20ug

Human Nucleolar protein 58 (NOP58)

1-CSB-EP896703HU Cusabio
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  • 100ug
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Description: Recombinant Human Nucleolar protein 58(NOP58) expressed in E.coli

OCOA10466-20UG - NOP58 Protein Lysate

OCOA10466-20UG Aviva Systems Biology 20ug 169 EUR

NOP58 Over-expression Lysate Product

GWB-984395 GenWay Biotech 0.1 mg Ask for price

NOP58 Polyclonal Antibody, HRP Conjugated

A54767 EpiGentek
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  • 100 µg
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NOP58 Polyclonal Antibody, FITC Conjugated

A54766 EpiGentek
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  • 100 µg
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OPCA02561-1MG - NOP58 Recombinant Protein

OPCA02561-1MG Aviva Systems Biology 1mg 1379 EUR

OPCA02561-20UG - NOP58 Recombinant Protein

OPCA02561-20UG Aviva Systems Biology 20ug 218 EUR

NOP58 Polyclonal Antibody, Biotin Conjugated

A54765 EpiGentek
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  • 100 µg
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OPCA02561-100UG - NOP58 Recombinant Protein

OPCA02561-100UG Aviva Systems Biology 100ug 323 EUR

Nop58 sgRNA CRISPR Lentivector set (Rat)

K6841801 ABM 3 x 1.0 ug 406.8 EUR

Nop58 sgRNA CRISPR Lentivector set (Mouse)

K4828601 ABM 3 x 1.0 ug 406.8 EUR

NOP58 sgRNA CRISPR Lentivector set (Human)

K1441001 ABM 3 x 1.0 ug 406.8 EUR

Recombinant Human Nucleolar protein 58 (NOP58)

CSB-EP896703HU Cusabio 4846 mg Ask for price

Recombinant Human Nucleolar protein 58(NOP58)

AP71631 SAB 1mg 1978 EUR

AAP56779-100UG - NOP58 Peptide - middle region

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NOP58 3'UTR GFP Stable Cell Line

TU065825 ABM 1.0 ml 1825.2 EUR

Nop58 3'UTR GFP Stable Cell Line

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NOP58 Protein Vector (Rat) (pPM-C-HA)

PV285644 ABM 500 ng 723.6 EUR

NOP58 Protein Vector (Rat) (pPB-C-His)

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NOP58 Protein Vector (Rat) (pPB-N-His)

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NOP58 Protein Vector (Rat) (pPM-C-His)

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NOP58 Protein Vector (Human) (pPM-C-HA)

PV028631 ABM 500 ng 394.8 EUR

NOP58 Protein Vector (Mouse) (pPM-C-HA)

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NOP58 Protein Vector (Human) (pPB-C-His)

PV028629 ABM 500 ng 394.8 EUR

NOP58 Protein Vector (Human) (pPB-N-His)

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NOP58 Protein Vector (Human) (pPM-C-His)

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NOP58 Protein Vector (Mouse) (pPB-C-His)

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Nop58 3'UTR Luciferase Stable Cell Line

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NOP58 3'UTR Luciferase Stable Cell Line

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Human Nucleolar protein 58, NOP58 ELISA KIT

ELI-38275h Lifescience Market 96 Tests 988.8 EUR

Mouse Nucleolar protein 58, Nop58 ELISA KIT

ELI-38276m Lifescience Market 96 Tests 1038 EUR

Human Nucleolar protein 58(NOP58)ELISA Kit

QY-E03190 Qayee Biotechnology 96T 472.8 EUR

Nop58 sgRNA CRISPR Lentivector (Rat) (Target 1)

K6841802 ABM 1.0 ug DNA 184.8 EUR

Nop58 sgRNA CRISPR Lentivector (Rat) (Target 2)

K6841803 ABM 1.0 ug DNA 184.8 EUR

Nop58 sgRNA CRISPR Lentivector (Rat) (Target 3)

K6841804 ABM 1.0 ug DNA 184.8 EUR

Human NOP58 Over-expressing Stable Cell Line

ABC-X2076 AcceGen 1 vial Ask for price
Description: Gentaur can provide custom lentiviral constructs expressing any genes of interest as long as it is less than about 3 kb. Lentiviral technology enables us to efficiently generate stable expression lines which are then selected for moderate or high expressers, depending on the experimental requirements. If you are interested in specific lentiviral DNA constructs or have further questions, please contact us to discuss the details. NOP58 NOP58 ribonucleoprotein homolog (yeast) [ Homo sapiens ] http://www.ncbi.nlm.nih.gov/gene/51602

Nop58 sgRNA CRISPR Lentivector (Mouse) (Target 1)

K4828602 ABM 1.0 ug DNA 184.8 EUR

Nop58 sgRNA CRISPR Lentivector (Mouse) (Target 2)

K4828603 ABM 1.0 ug DNA 184.8 EUR

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K1441002 ABM 1.0 ug DNA 184.8 EUR

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Inferential statistics will be used to evaluate measures of agreement between participants (Kendall’s coefficient of concordance) and stability between rounds (Wilcoxon rank-sum test). Statements achieving consensus in round 3 will provide expert recommendations of the key exercise and dosage variables in the management of chronic non-specific neck pain.Ethical approval was provided by the University of Birmingham Ethics Committee (Ref:ERN_19-1857). Results will be disseminated through peer-reviewed publications and conference presentations.