Clinical guidelines and systematic reviews recommend exercise in the management of chronic non-specific neck pain. Although exercise training programmes that consist of both motor control exercise and exercises for the superficial cervical muscles (segmental exercises) are effective, the exercise variables including dosage vary considerably across trials or are poorly reported.
This study aims to gain expert consensus on these exercise variables so that they can be described clearly using intervention reporting checklists to inform clinical practice and future clinical trials.This protocol for an international Delphi study is informed by the Guidance on Conducting and REporting DElphi Studies recommendations and published to ensure quality, rigour and transparency.
The study will consist of three rounds using anonymous online questionnaires. Expert exercise professionals (physiotherapists, strength and conditioning coaches and so on) and academics in neck pain management will be identified through literature searches, peer referral and social media calls for expression of interest. In round 1, participants will answer open-ended questions informed by intervention and exercise reporting checklists. Responses will be analysed thematically by two independent reviewers.
In round 2, participants will rate their level of agreement with statements generated from round 1 and previous clinical trials using a 5-point Likert scale where 1=strongly disagree and 5=strongly agree. In round 3, participants will re-rate their agreement with statements that achieved consensus in round 2. Statements reaching consensus among participants must meet progressively increased a priori criteria at rounds 2 and 3, measured using descriptive statistics: median, IQR and percentage agreement.
Nop58 (untagged) - Mouse NOP58 ribonucleoprotein homolog (yeast) (Nop58), (10ug) |
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MC203524 | Origene Technologies GmbH | 10 µg | Ask for price |
NOP58 (GFP-tagged) - Human NOP58 ribonucleoprotein homolog (yeast) (NOP58) |
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RG207514 | Origene Technologies GmbH | 10 µg | Ask for price |
NOP58 (Myc-DDK-tagged)-Human NOP58 ribonucleoprotein homolog (yeast) (NOP58) |
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RC207514 | Origene Technologies GmbH | 10 µg | Ask for price |
Nop58 (Myc-DDK-tagged) - Mouse NOP58 ribonucleoprotein homolog (yeast) (Nop58) |
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MR207552 | Origene Technologies GmbH | 10 µg | Ask for price |
Human NOP58 Ribonucleoprotein (NOP58) ELISA Kit |
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abx381850-96tests | Abbexa | 96 tests | 1093.2 EUR |
Nop58 Ribonucleoprotein Homolog (Yeast) (NOP58) Antibody |
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20-abx114154 | Abbexa |
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NOP58 siRNA |
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20-abx926153 | Abbexa |
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NOP58 siRNA |
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20-abx926154 | Abbexa |
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NOP58 siRNA |
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20-abx903599 | Abbexa |
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NOP58 Antibody |
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1-CSB-PA015940GA01HU | Cusabio |
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Description: A polyclonal antibody against NOP58. Recognizes NOP58 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB |
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NOP58 Antibody |
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E94749 | EnoGene | 100μg | 255 EUR |
Description: Available in various conjugation types. |
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NOP58 Antibody |
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DF13192 | Affbiotech | 200ul | 420 EUR |
NOP58 Antibody |
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DF13192-100ul | Affinity Biosciences | 100ul | 280 EUR |
NOP58 Antibody |
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DF13192-200ul | Affinity Biosciences | 200ul | 350 EUR |
NOP58 antibody |
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E39-10461 | EnoGene | 100ug/100ul | 225 EUR |
Description: Available in various conjugation types. |
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NOP58 Antibody |
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E308307 | EnoGene | 200ul | 275 EUR |
Description: Available in various conjugation types. |
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NOP58 antibody |
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70R-18924 | Fitzgerald | 50 ul | 289 EUR |
Description: Rabbit polyclonal NOP58 antibody |
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NOP58 Antibody |
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CAC09967-100ug | Biomatik Corporation | 100ug | 314 EUR |
NOP58 Antibody |
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CAC09967-50ug | Biomatik Corporation | 50ug | 199.2 EUR |
NOP58 Antibody |
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1-CSB-PA896703LA01HU | Cusabio |
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Description: A polyclonal antibody against NOP58. Recognizes NOP58 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF; Recommended dilution: WB:1:500-1:5000, IF:1:50-1:200 |
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Lenti ORF clone of Nop58 (mGFP-tagged) - Mouse NOP58 ribonucleoprotein homolog (yeast) (Nop58) |
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MR207552L4 | Origene Technologies GmbH | 10 µg | Ask for price |
NOP5/NOP58 antibody |
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70R-3412 | Fitzgerald | 50 ug | 467 EUR |
Description: Rabbit polyclonal NOP5/NOP58 antibody raised against the middle region of NOP5/NOP58 |
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Lenti ORF clone of Nop58 (Myc-DDK-tagged) - Mouse NOP58 ribonucleoprotein homolog (yeast) (Nop58) |
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MR207552L3 | Origene Technologies GmbH | 10 µg | Ask for price |
NOP58 Rabbit pAb |
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E2514129 | EnoGene | 100ul | 225 EUR |
Description: Available in various conjugation types. |
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NOP58 Rabbit pAb |
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E2504749 | EnoGene | 100ul | 225 EUR |
Description: Available in various conjugation types. |
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NOP58 Rabbit pAb |
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A14129-100ul | Abclonal | 100 ul | 369.6 EUR |
NOP58 Rabbit pAb |
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A14129-200ul | Abclonal | 200 ul | 550.8 EUR |
NOP58 Rabbit pAb |
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A14129-20ul | Abclonal | 20 ul | 219.6 EUR |
NOP58 Rabbit pAb |
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A14129-50ul | Abclonal | 50 ul | 267.6 EUR |
NOP58 Rabbit pAb |
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A4749-100ul | Abclonal | 100 ul | 369.6 EUR |
NOP58 Rabbit pAb |
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A4749-200ul | Abclonal | 200 ul | 550.8 EUR |
NOP58 Rabbit pAb |
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A4749-20ul | Abclonal | 20 ul | 219.6 EUR |
NOP58 Rabbit pAb |
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A4749-50ul | Abclonal | 50 ul | 267.6 EUR |
NOP58 Rabbit pAb |
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E2827378 | EnoGene | 100ul | 225 EUR |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
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NOP58 Rabbit pAb |
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E2127378 | EnoGene | 100ul | 225 EUR |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
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anti- NOP58 antibody |
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FNab05796 | FN Test | 100µg | 606.3 EUR |
Description: Antibody raised against NOP58 |
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NOP58 Blocking Peptide |
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DF13192-BP | Affbiotech | 1mg | 234 EUR |
NOP58 Polyclonal Antibody |
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28438 | SAB | 100ul | 439 EUR |
NOP58 Polyclonal Antibody |
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28438-100ul | SAB | 100ul | 302.4 EUR |
NOP58 Polyclonal Antibody |
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28438-50ul | SAB | 50ul | 224.4 EUR |
NOP58 Polyclonal Antibody |
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30604 | SAB | 100ul | 439 EUR |
NOP58 Polyclonal Antibody |
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30604-100ul | SAB | 100ul | 302.4 EUR |
NOP58 Polyclonal Antibody |
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30604-50ul | SAB | 50ul | 224.4 EUR |
NOP58 Polyclonal Antibody |
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E914129 | EnoGene | 100ul | 225 EUR |
Description: Available in various conjugation types. |
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NOP58 Polyclonal Antibody |
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A54768 | EpiGentek |
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NOP58 Polyclonal Antibody |
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A71472 | EpiGentek | 50 μl | 408 EUR |
NOP5/NOP58 Blocking Peptide |
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33R-5398 | Fitzgerald | 100 ug | 119 EUR |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of NOP5/NOP58 antibody, catalog no. 70R-3412 |
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Lenti ORF particles, Nop58 (GFP-tagged) - Mouse NOP58 ribonucleoprotein homolog (yeast) (Nop58), 200ul, >10^7 TU/mL |
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MR207552L4V | Origene Technologies GmbH | 200 µl | Ask for price |
Lenti ORF particles, NOP58 (mGFP-tagged) - Human NOP58 ribonucleoprotein homolog (yeast) (NOP58), 200ul, >10^7 TU/mL |
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RC207514L4V | Origene Technologies GmbH | 200 µl | Ask for price |
Lenti ORF particles, NOP58 (Myc-DDK tagged) - Human NOP58 ribonucleoprotein homolog (yeast) (NOP58), 200ul, >10^7 TU/mL |
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RC207514L3V | Origene Technologies GmbH | 200 µl | Ask for price |
Lenti ORF particles, Nop58 (Myc-DDK-tagged) - Mouse NOP58 ribonucleoprotein homolog (yeast) (Nop58), 200ul, >10^7 TU/mL |
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MR207552L3V | Origene Technologies GmbH | 200 µl | Ask for price |
NOP58 ELISA KIT|Human |
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EF001287 | Lifescience Market | 96 Tests | 826.8 EUR |
Rat NOP58 shRNA Plasmid |
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20-abx986026 | Abbexa |
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Human NOP58 shRNA Plasmid |
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20-abx959853 | Abbexa |
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Mouse NOP58 shRNA Plasmid |
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20-abx974581 | Abbexa |
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NOP58 Antibody, HRP conjugated |
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1-CSB-PA896703LB01HU | Cusabio |
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Description: A polyclonal antibody against NOP58. Recognizes NOP58 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA |
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NOP58 Recombinant Protein (Rat) |
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RP214229 | ABM | 100 ug | Ask for price |
NOP58 Antibody, FITC conjugated |
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1-CSB-PA896703LC01HU | Cusabio |
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Description: A polyclonal antibody against NOP58. Recognizes NOP58 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA |
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NOP58 Recombinant Protein (Mouse) |
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RP154577 | ABM | 100 ug | Ask for price |
OACA06524-50UG - NOP58 Antibody |
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OACA06524-50UG | Aviva Systems Biology | 50ug | 179 EUR |
NOP58 Recombinant Protein (Human) |
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RP021472 | ABM | 100 ug | Ask for price |
NOP58 Antibody, Biotin conjugated |
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1-CSB-PA896703LD01HU | Cusabio |
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Description: A polyclonal antibody against NOP58. Recognizes NOP58 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA |
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OACA06524-100UG - NOP58 Antibody |
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OACA06524-100UG | Aviva Systems Biology | 100ug | 319 EUR |
NOP58 Rabbit Polyclonal Antibody |
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E10G03552 | EnoGene | 100 μl | 275 EUR |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
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NOP58 Rabbit Polyclonal Antibody |
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E10G10558 | EnoGene | 100 μl | 275 EUR |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
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NOP58 Polyclonal Conjugated Antibody |
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C30604 | SAB | 100ul | 476.4 EUR |
NOP58 Polyclonal Conjugated Antibody |
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C28438 | SAB | 100ul | 476.4 EUR |
Lenti ORF clone of Human NOP58 ribonucleoprotein homolog (yeast) (NOP58), mGFP tagged |
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RC207514L4 | Origene Technologies GmbH | 10 µg | Ask for price |
Nop58 ORF Vector (Rat) (pORF) |
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ORF071411 | ABM | 1.0 ug DNA | 607.2 EUR |
NOP58 ORF Vector (Human) (pORF) |
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ORF007158 | ABM | 1.0 ug DNA | 114 EUR |
Nop58 ORF Vector (Mouse) (pORF) |
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ORF051527 | ABM | 1.0 ug DNA | 607.2 EUR |
Lenti ORF clone of Human NOP58 ribonucleoprotein homolog (yeast) (NOP58), Myc-DDK-tagged |
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RC207514L3 | Origene Technologies GmbH | 10 µg | Ask for price |
3`UTR clone of NOP58 ribonucleoprotein homolog (yeast) (NOP58) for miRNA target validation |
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SC202891 | Origene Technologies GmbH | 10 µg | Ask for price |
Human NOP58 Protein Lysate 20ug |
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IHUNOP58PLLY20UG | Innovative research | each | 213 EUR |
Description: Human NOP58 Protein Lysate 20ug |
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Human Nucleolar protein 58 (NOP58) |
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1-CSB-EP896703HU | Cusabio |
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Description: Recombinant Human Nucleolar protein 58(NOP58) expressed in E.coli |
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OCOA10466-20UG - NOP58 Protein Lysate |
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OCOA10466-20UG | Aviva Systems Biology | 20ug | 169 EUR |
NOP58 Over-expression Lysate Product |
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GWB-984395 | GenWay Biotech | 0.1 mg | Ask for price |
NOP58 Polyclonal Antibody, HRP Conjugated |
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A54767 | EpiGentek |
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NOP58 Polyclonal Antibody, FITC Conjugated |
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A54766 | EpiGentek |
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OPCA02561-1MG - NOP58 Recombinant Protein |
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OPCA02561-1MG | Aviva Systems Biology | 1mg | 1379 EUR |
OPCA02561-20UG - NOP58 Recombinant Protein |
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OPCA02561-20UG | Aviva Systems Biology | 20ug | 218 EUR |
NOP58 Polyclonal Antibody, Biotin Conjugated |
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A54765 | EpiGentek |
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OPCA02561-100UG - NOP58 Recombinant Protein |
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OPCA02561-100UG | Aviva Systems Biology | 100ug | 323 EUR |
Nop58 sgRNA CRISPR Lentivector set (Rat) |
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K6841801 | ABM | 3 x 1.0 ug | 406.8 EUR |
Nop58 sgRNA CRISPR Lentivector set (Mouse) |
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K4828601 | ABM | 3 x 1.0 ug | 406.8 EUR |
NOP58 sgRNA CRISPR Lentivector set (Human) |
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K1441001 | ABM | 3 x 1.0 ug | 406.8 EUR |
Recombinant Human Nucleolar protein 58 (NOP58) |
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CSB-EP896703HU | Cusabio | 4846 mg | Ask for price |
Recombinant Human Nucleolar protein 58(NOP58) |
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AP71631 | SAB | 1mg | 1978 EUR |
AAP56779-100UG - NOP58 Peptide - middle region |
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AAP56779-100UG | Aviva Systems Biology | 100ug | 99 EUR |
NOP58 3'UTR GFP Stable Cell Line |
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TU065825 | ABM | 1.0 ml | 1825.2 EUR |
Nop58 3'UTR GFP Stable Cell Line |
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TU164212 | ABM | 1.0 ml | Ask for price |
Nop58 3'UTR GFP Stable Cell Line |
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TU264085 | ABM | 1.0 ml | Ask for price |
NOP58 Protein Vector (Rat) (pPM-C-HA) |
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PV285644 | ABM | 500 ng | 723.6 EUR |
NOP58 Protein Vector (Rat) (pPB-C-His) |
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PV285642 | ABM | 500 ng | 723.6 EUR |
NOP58 Protein Vector (Rat) (pPB-N-His) |
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PV285643 | ABM | 500 ng | 723.6 EUR |
NOP58 Protein Vector (Rat) (pPM-C-His) |
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PV285645 | ABM | 500 ng | 723.6 EUR |
NOP58 Protein Vector (Human) (pPM-C-HA) |
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PV028631 | ABM | 500 ng | 394.8 EUR |
NOP58 Protein Vector (Mouse) (pPM-C-HA) |
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PV206108 | ABM | 500 ng | 723.6 EUR |
NOP58 Protein Vector (Human) (pPB-C-His) |
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PV028629 | ABM | 500 ng | 394.8 EUR |
NOP58 Protein Vector (Human) (pPB-N-His) |
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PV028630 | ABM | 500 ng | 394.8 EUR |
NOP58 Protein Vector (Human) (pPM-C-His) |
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PV028632 | ABM | 500 ng | 394.8 EUR |
NOP58 Protein Vector (Mouse) (pPB-C-His) |
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PV206106 | ABM | 500 ng | 723.6 EUR |
NOP58 Protein Vector (Mouse) (pPB-N-His) |
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PV206107 | ABM | 500 ng | 723.6 EUR |
NOP58 Protein Vector (Mouse) (pPM-C-His) |
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PV206109 | ABM | 500 ng | 723.6 EUR |
Nop58 3'UTR Luciferase Stable Cell Line |
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TU114212 | ABM | 1.0 ml | Ask for price |
NOP58 3'UTR Luciferase Stable Cell Line |
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TU015825 | ABM | 1.0 ml | 1825.2 EUR |
Nop58 3'UTR Luciferase Stable Cell Line |
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TU214085 | ABM | 1.0 ml | Ask for price |
Human Nucleolar protein 58, NOP58 ELISA KIT |
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ELI-38275h | Lifescience Market | 96 Tests | 988.8 EUR |
Mouse Nucleolar protein 58, Nop58 ELISA KIT |
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ELI-38276m | Lifescience Market | 96 Tests | 1038 EUR |
Human Nucleolar protein 58(NOP58)ELISA Kit |
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QY-E03190 | Qayee Biotechnology | 96T | 472.8 EUR |
Nop58 sgRNA CRISPR Lentivector (Rat) (Target 1) |
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K6841802 | ABM | 1.0 ug DNA | 184.8 EUR |
Nop58 sgRNA CRISPR Lentivector (Rat) (Target 2) |
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K6841803 | ABM | 1.0 ug DNA | 184.8 EUR |
Nop58 sgRNA CRISPR Lentivector (Rat) (Target 3) |
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K6841804 | ABM | 1.0 ug DNA | 184.8 EUR |
Human NOP58 Over-expressing Stable Cell Line |
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ABC-X2076 | AcceGen | 1 vial | Ask for price |
Description: Gentaur can provide custom lentiviral constructs expressing any genes of interest as long as it is less than about 3 kb. Lentiviral technology enables us to efficiently generate stable expression lines which are then selected for moderate or high expressers, depending on the experimental requirements. If you are interested in specific lentiviral DNA constructs or have further questions, please contact us to discuss the details. NOP58 NOP58 ribonucleoprotein homolog (yeast) [ Homo sapiens ] http://www.ncbi.nlm.nih.gov/gene/51602 |
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Nop58 sgRNA CRISPR Lentivector (Mouse) (Target 1) |
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K4828602 | ABM | 1.0 ug DNA | 184.8 EUR |
Nop58 sgRNA CRISPR Lentivector (Mouse) (Target 2) |
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K4828603 | ABM | 1.0 ug DNA | 184.8 EUR |
Nop58 sgRNA CRISPR Lentivector (Mouse) (Target 3) |
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K4828604 | ABM | 1.0 ug DNA | 184.8 EUR |
NOP58 sgRNA CRISPR Lentivector (Human) (Target 1) |
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K1441002 | ABM | 1.0 ug DNA | 184.8 EUR |
NOP58 sgRNA CRISPR Lentivector (Human) (Target 2) |
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K1441003 | ABM | 1.0 ug DNA | 184.8 EUR |
NOP58 sgRNA CRISPR Lentivector (Human) (Target 3) |
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K1441004 | ABM | 1.0 ug DNA | 184.8 EUR |
Inferential statistics will be used to evaluate measures of agreement between participants (Kendall’s coefficient of concordance) and stability between rounds (Wilcoxon rank-sum test). Statements achieving consensus in round 3 will provide expert recommendations of the key exercise and dosage variables in the management of chronic non-specific neck pain.Ethical approval was provided by the University of Birmingham Ethics Committee (Ref:ERN_19-1857). Results will be disseminated through peer-reviewed publications and conference presentations.