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Circadian Bio-engineering Research Committee Presentation

Circadian Bio-engineering Research Committee Presentation

Atto Kronos Spring Bio Conference

  • Human KRT8(Keratin 8) ELISA Kit
  • Human CFP(Complement Factor P) ELISA Kit
  • Human GDF15(Growth Differentiation Factor 15) ELISA Kit
  • Mouse TRAIL(Tumor Necrosis Factor Related Apoptosis Inducing Ligand) ELISA Kit
  • Chicken IL8(Interleukin 8) ELISA Kit
  • Human DCN(Decorin) ELISA Kit
  • Rabbit FDP(Fibrinogen Degradation Product) ELISA Kit
  • Human PLTP(Phospholipid Transfer Protein) ELISA Kit
  • Rabbit OC(Osteocalcin) ELISA Kit
  • Human KLK2(Kallikrein 2) ELISA Kit
  • Mouse F13B(Coagulation Factor XIII B Polypeptide) ELISA Kit
  • Human GSTa4(Glutathione S Transferase Alpha 4) ELISA Kit
  • Human GLUT2(Glucose Transporter 2) ELISA Kit
  • Human ANXA11(Annexin A11) ELISA Kit
  • Human PPARd(Peroxisome Proliferator Activated Receptor Delta) ELISA Kit
  • Human ANXA1(Annexin A1) ELISA Kit
  • Human FXR(Farnesoid X Receptor) ELISA Kit
  • Human PRDX5(Peroxiredoxin 5) ELISA Kit
  • Human LXRa(Liver X Receptor Alpha) ELISA Kit
  • Rabbit OxLDL(Oxidized Low Density Lipoprotein) ELISA Kit
  • Mouse PKCd(Protein Kinase C Delta) ELISA Kit
  • Human DSP(Desmoplakin) ELISA Kit
  • Rat HBEGF(Heparin Binding Epidermal Growth Factor Like Growth Factor) ELISA Kit
  • Human GKN1(Gastrokine 1) ELISA Kit
  • Human MMP14(Matrix Metalloproteinase 14) ELISA Kit
  • Human FCN1(Ficolin 1) ELISA Kit
  • Human PDGFRa(Platelet Derived Growth Factor Receptor Alpha) ELISA Kit
  • Human MASP2(Mannose Associated Serine Protease 2) ELISA Kit
  • Human PDGFRb(Platelet Derived Growth Factor Receptor Beta) ELISA Kit
  • Human C5b-9(Terminal Complement Complex C5b-9) ELISA Kit
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  • Human NOX4(Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4) ELISA Kit
  • Rat TRAIL(Tumor Necrosis Factor Related Apoptosis Inducing Ligand) ELISA Kit
  • Human ETRB(Endothelin Receptor B) ELISA Kit
  • Mouse PP(Pancreatic Polypeptide) ELISA Kit
  • Human GUSb(Glucuronidase Beta) ELISA Kit
  • Rat ITaC(Interferon Inducible T-Cell Alpha Chemoattractant) ELISA Kit
  • Can a teacher-led mindfulness intervention for new school entrants improve child outcomes? Protocol for a school cluster randomised controlled trial.
  • Mouse GUSb(Glucuronidase Beta) ELISA Kit
  • Human TJP1(Tight Junction Protein 1) ELISA Kit
  • Patterns of Metastasis in Merkel Cell Carcinoma.
  • Mouse TFF2(Trefoil Factor 2) ELISA Kit
  • Human LN(Laminin) ELISA Kit
  • Consensus on the exercise and dosage variables of an exercise training programme for chronic non-specific neck pain: protocol for an international e-Delphi study.
  • Mouse GCK(Glucokinase) ELISA Kit
  • Rat ENG(Endoglin) ELISA Kit
  • Rat GCK(Glucokinase) ELISA Kit
  • Mouse POMC(Proopiomelanocortin) ELISA Kit
  • Human MBP(Myelin Basic Protein) ELISA Kit
  • Human ETRA(Endothelin Receptor A) ELISA Kit
  • Rat PECAM1(Platelet/Endothelial Cell Adhesion Molecule) ELISA Kit
  • Human PAPPA2(Pappalysin 2) ELISA Kit
  • Mouse Ntn1(Netrin 1) ELISA Kit
  • Rabbit C5a(Complement Component 5a) ELISA Kit
  • Chicken IL10(Interleukin 10) ELISA Kit
  • Human PCI(Protein C Inhibitor) ELISA Kit
  • Mouse VCL(Vinculin) ELISA Kit
  • Human FBLN5(Fibulin 5) ELISA Kit
  • Mouse NOX4(Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4) ELISA Kit
  • Human DSPP(Dentin Sialophosphoprotein) ELISA Kit
  • Mouse OCT4(Octamer Binding Transcription Factor 4) ELISA Kit
  • Rabbit NSE(Enolase, Neuron Specific) ELISA Kit
  • Mouse gGT1(Gamma-Glutamyltransferase 1) ELISA Kit
  • Human CBG(Corticosteroid Binding Globulin) ELISA Kit
  • Rabbit MMP13(Matrix Metalloproteinase 13) ELISA Kit
  • Human ANXA6(Annexin A6) ELISA Kit
  • Mouse FGb(Fibrinogen Beta) ELISA Kit
  • Human TMPRSS2(Transmembrane Protease, Serine 2) ELISA Kit
  • Mouse GC(Glucagon) ELISA Kit
  • Human TDGF1(Teratocarcinoma Derived Growth Factor 1) ELISA Kit
  • Rat aHSG(Alpha-2-Heremans Schmid Glycoprotein) ELISA Kit
  • Human COL10(Collagen Type X) ELISA Kit
  • Rat INHbC(Inhibin Beta C) ELISA Kit
  • Human TOP1(Topoisomerase I) ELISA Kit
  • Human GAL3(Galectin 3) ELISA Kit
  • Human FOLR1(Folate Receptor 1, Adult) ELISA Kit
  • Human TGFbI(Transforming Growth Factor Beta Induced Protein) ELISA Kit
  • Mouse BAFF(B-Cell Activating Factor) ELISA Kit
  • Mouse TGFbI(Transforming Growth Factor Beta Induced Protein) ELISA Kit
  • Human ICAM4(Intercellular Adhesion Molecule 4) ELISA Kit
  • Human Ki67P(Ki-67 Protein) ELISA Kit
  • Mouse PHB(Prohibitin) ELISA Kit
  • Mouse LBP(Lipopolysaccharide Binding Protein) ELISA Kit
  • Rat LN(Laminin) ELISA Kit
  • Mouse APOC1(Apolipoprotein C1) ELISA Kit
  • Human PDPN(Podoplanin) ELISA Kit
  • Human OLFM4(Olfactomedin 4) ELISA Kit
  • Human AGR2(Anterior Gradient Protein 2) ELISA Kit
  • Mouse FGL2(Fibrinogen Like Protein 2) ELISA Kit
  • Human PSPN(Persephin) ELISA Kit
  • Human FcgR3B(Fc Fragment Of IgG Low Affinity IIIb Receptor) ELISA Kit
  • Human SOST(Sclerostin) ELISA Kit
  • Human CFI(Complement Factor I) ELISA Kit
  • Rat MIP1b(Macrophage Inflammatory Protein 1 Beta) ELISA Kit
  • Human RYR2(Ryanodine Receptor 2, Cardiac) ELISA Kit
  • Rat MDC(Macrophage Derived Chemokine) ELISA Kit
  • Human PKR1(Prokineticin Receptor 1) ELISA Kit
  • Rat MCSF(Colony Stimulating Factor 1, Macrophage) ELISA Kit
  • Rat PK(Pyruvate Kinase, Liver And RBC) ELISA Kit
  • Rat MCP3(Monocyte Chemotactic Protein 3) ELISA Kit
  • Rabbit CCKAR(Cholecystokinin A Receptor) ELISA Kit
  • Mouse MCP3(Monocyte Chemotactic Protein 3) ELISA Kit
  • Mouse GAL3(Galectin 3) ELISA Kit
  • Rat SELL(Selectin, Leukocyte) ELISA Kit
  • Rat GAL3(Galectin 3) ELISA Kit
  • Rat LEPR(Leptin Receptor) ELISA Kit
  • Chicken NGF(Nerve Growth Factor) ELISA Kit
  • Rat IL5(Interleukin 5) ELISA Kit
  • Mouse CTSL(Cathepsin L) ELISA Kit
  • Rat IL3(Interleukin 3) ELISA Kit
  • Rat CTSL(Cathepsin L) ELISA Kit
  • Rat NAGase(N-Acetyl Beta-D-Glucosaminidase) ELISA Kit
  • Human GAL7(Galectin 7) ELISA Kit
  • Mouse NAGase(N-Acetyl Beta-D-Glucosaminidase) ELISA Kit
  • Human GAL9(Galectin 9) ELISA Kit
  • Mouse IL1R1(Interleukin 1 Receptor Type I) ELISA Kit
  • Mouse GAL9(Galectin 9) ELISA Kit
  • Mouse IL1R2(Interleukin 1 Receptor Type II) ELISA Kit
  • Rat GAL9(Galectin 9) ELISA Kit
  • Rat IL17(Interleukin 17) ELISA Kit
  • Rabbit CKM(Creatine Kinase, Muscle) ELISA Kit
  • Rat IL15(Interleukin 15) ELISA Kit
  • Mouse FABP5(Fatty Acid Binding Protein 5, Epidermal) ELISA Kit
  • Rat IL13(Interleukin 13) ELISA Kit
  • Human PK2(Prokineticin 2) ELISA Kit
  • Human GHRH(Growth Hormone Releasing Hormone) ELISA Kit
  • Mouse PK2(Prokineticin 2) ELISA Kit
  • Mouse GHRH(Growth Hormone Releasing Hormone) ELISA Kit
  • Rabbit ACE(Angiotensin I Converting Enzyme) ELISA Kit
  • Rat PTH(Parathyroid Hormone) ELISA Kit
  • Human SOD3(Superoxide Dismutase 3, Extracellular) ELISA Kit
  • Mouse PTH(Parathyroid Hormone) ELISA Kit
  • Mouse SOD3(Superoxide Dismutase 3, Extracellular) ELISA Kit
  • Rat CTGF(Connective Tissue Growth Factor) ELISA Kit
  • Rat SOD3(Superoxide Dismutase 3, Extracellular) ELISA Kit
  • Mouse CTGF(Connective Tissue Growth Factor) ELISA Kit
  • Rabbit SOD3(Superoxide Dismutase 3, Extracellular) ELISA Kit
  • Rat TF(Tissue Factor) ELISA Kit
  • Mouse PEDF(Pigment Epithelium Derived Factor) ELISA Kit
  • Mouse TF(Tissue Factor) ELISA Kit
  • Mouse ELA4(Elastase 4) ELISA Kit
  • Rat tPA(Plasminogen Activator, Tissue) ELISA Kit
  • Mouse S100B(S100 Calcium Binding Protein B) ELISA Kit
  • Mouse tPA(Plasminogen Activator, Tissue) ELISA Kit
  • Mouse TARC(Thymus Activation Regulated Chemokine) ELISA Kit
  • Rat COL3(Collagen Type III) ELISA Kit
  • Mouse IL31(Interleukin 31) ELISA Kit
  • Mouse COL3(Collagen Type III) ELISA Kit
  • Human NES1(Nesfatin 1) ELISA Kit
  • Human PIINP(Procollagen II N-Terminal Propeptide) ELISA Kit
  • Chicken TIMP3(Tissue Inhibitors Of Metalloproteinase 3) ELISA Kit
  • Rat PIINP(Procollagen II N-Terminal Propeptide) ELISA Kit
  • Rabbit TIMP3(Tissue Inhibitors Of Metalloproteinase 3) ELISA Kit
  • Human PDGFA(Platelet Derived Growth Factor Subunit A) ELISA Kit
  • Human MUC6(Mucin 6) ELISA Kit
  • Human TM(Thrombomodulin) ELISA Kit
  • Human SYNPO(Synaptopodin) ELISA Kit
  • Mouse TM(Thrombomodulin) ELISA Kit
  • Chicken CAV1(Caveolin 1) ELISA Kit
  • Rat TM(Thrombomodulin) ELISA Kit
  • Rabbit TIMP4(Tissue Inhibitors Of Metalloproteinase 4) ELISA Kit
  • Human FDP(Fibrinogen Degradation Product) ELISA Kit
  • Rabbit TNFb(Tumor Necrosis Factor Beta) ELISA Kit
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  • Rat FDP(Fibrinogen Degradation Product) ELISA Kit
  • Mouse PROC(Protein C) ELISA Kit
  • Human PAI2(Plasminogen Activator Inhibitor 2) ELISA Kit
  • Rat PROC(Protein C) ELISA Kit
  • Mouse PAI2(Plasminogen Activator Inhibitor 2) ELISA Kit
  • Human COL4a1(Collagen Type IV Alpha 1) ELISA Kit
  • Rat PAI2(Plasminogen Activator Inhibitor 2) ELISA Kit
  • Human EVPL(Envoplakin) ELISA Kit
  • Mouse PAI1(Plasminogen Activator Inhibitor 1) ELISA Kit
  • Chicken IL13(Interleukin 13) ELISA Kit
  • Rat PAI1(Plasminogen Activator Inhibitor 1) ELISA Kit
  • Mouse COL4a1(Collagen Type IV Alpha 1) ELISA Kit
  • Mouse ICAM2(Intercellular Adhesion Molecule 2) ELISA Kit
  • Rat COL4a1(Collagen Type IV Alpha 1) ELISA Kit
  • Human NSE(Enolase, Neuron Specific) ELISA Kit
  • Human ADIPOR1(Adiponectin Receptor 1) ELISA Kit
  • Mouse NSE(Enolase, Neuron Specific) ELISA Kit
  • Mouse ADIPOR1(Adiponectin Receptor 1) ELISA Kit
  • Rat NSE(Enolase, Neuron Specific) ELISA Kit
  • Rat ADIPOR1(Adiponectin Receptor 1) ELISA Kit
  • Rat BNP(Brain Natriuretic Peptide) ELISA Kit
  • Mouse OLFM4(Olfactomedin 4) ELISA Kit
  • Human ES(Endostatin) ELISA Kit
  • Mouse SCCA2(Squamous Cell Carcinoma Antigen 2) ELISA Kit
  • Mouse ES(Endostatin) ELISA Kit
  • Human FGFR1(Fibroblast Growth Factor Receptor 1) ELISA Kit
  • Mouse IgE(Immunoglobulin E) ELISA Kit
  • Mouse FGF23(Fibroblast Growth Factor 23) ELISA Kit
  • Rat IgE(Immunoglobulin E) ELISA Kit
  • Rat IGFBP6(Insulin Like Growth Factor Binding Protein 6) ELISA Kit
  • Mouse IgA(Immunoglobulin A) ELISA Kit
  • Human LCP1(Lymphocyte Cytosolic Protein 1) ELISA Kit
  • Rat IgA(Immunoglobulin A) ELISA Kit
  • Human CKB(Creatine Kinase, Brain) ELISA Kit
  • Rat VCAM1(Vascular Cell Adhesion Molecule 1) ELISA Kit
  • Mouse GPC4(Glypican 4) ELISA Kit
  • Rat FGF2(Fibroblast Growth Factor 2, Basic) ELISA Kit
  • Mouse IRF3(Interferon Regulatory Factor 3) ELISA Kit
  • Rat MMP9(Matrix Metalloproteinase 9) ELISA Kit
  • Human ECM1(Extracellular Matrix Protein 1) ELISA Kit
  • Rat NOX1(Nicotinamide Adenine Dinucleotide Phosphate Oxidase 1) ELISA Kit
  • Rabbit IL1RA(Interleukin 1 Receptor Antagonist) ELISA Kit
  • Chicken IL16(Interleukin 16) ELISA Kit
  • Rabbit IL18(Interleukin 18) ELISA Kit
  • Human TEP1(Telomerase Associated Protein 1) ELISA Kit
  • Human ACVB(Activin B) ELISA Kit
  • Rat FABP2(Fatty Acid Binding Protein 2, Intestinal) ELISA Kit
  • Human CD99(Cluster Of Differentiation 99) ELISA Kit
  • Mouse LIFR(Leukemia Inhibitory Factor Receptor) ELISA Kit
  • Human GLa(Galactosidase Alpha) ELISA Kit
  • Human NOSTRIN(Nitric Oxide Synthase Trafficker) ELISA Kit
  • Mouse PGC(Pepsinogen C) ELISA Kit
  • Rat CRH(Corticotropin Releasing Hormone) ELISA Kit
  • Rabbit IL1a(Interleukin 1 Alpha) ELISA Kit
  • Rat TRH(Thyrotropin Releasing Hormone) ELISA Kit
  • Mouse DEFb2(Defensin Beta 2) ELISA Kit
  • Rat MYO(Myoglobin) ELISA Kit
  • Mouse IgG1(Immunoglobulin G1) ELISA Kit
  • Mouse MYO(Myoglobin) ELISA Kit
  • Rat MMP12(Matrix Metalloproteinase 12) ELISA Kit
  • Human IL17(Interleukin 17) ELISA Kit
  • Mouse CYPB(Cyclophilin B) ELISA Kit
  • Human FIL1d(Interleukin 1 Delta) ELISA Kit
  • Rat CYPB(Cyclophilin B) ELISA Kit
  • Human S100B(S100 Calcium Binding Protein B) ELISA Kit
  • Human FGF10(Fibroblast Growth Factor 10) ELISA Kit
  • Rat S100B(S100 Calcium Binding Protein B) ELISA Kit
  • Mouse F1+2(Prothrombin Fragment 1+2) ELISA Kit
  • Mouse S100A11(S100 Calcium Binding Protein A11) ELISA Kit
  • Mouse CFD(Complement Factor D) ELISA Kit
  • Rat S100A11(S100 Calcium Binding Protein A11) ELISA Kit
  • Chicken IL5(Interleukin 5) ELISA Kit
  • Mouse COL1(Collagen Type I) ELISA Kit
  • Mouse TFR2(Transferrin Receptor 2) ELISA Kit
  • Rat COL1(Collagen Type I) ELISA Kit
  • Rat TFR2(Transferrin Receptor 2) ELISA Kit
  • Human COL2(Collagen Type II) ELISA Kit
  • Goat IL6(Interleukin 6) ELISA Kit
  • Mouse COL2(Collagen Type II) ELISA Kit
  • Cattle IL8(Interleukin 8) ELISA Kit
  • Rat COL2(Collagen Type II) ELISA Kit
  • Mouse AMH(Anti-Mullerian Hormone) ELISA Kit
  • Human PIIINP(Procollagen III N-Terminal Propeptide) ELISA Kit
  • Human UCN1(Urocortin 1) ELISA Kit
  • Mouse PIIINP(Procollagen III N-Terminal Propeptide) ELISA Kit
  • Chicken MIP1b(Macrophage Inflammatory Protein 1 Beta) ELISA Kit
  • Rat APOB100(Apolipoprotein B100) ELISA Kit
  • Rabbit MIP1b(Macrophage Inflammatory Protein 1 Beta) ELISA Kit
  • Human APOA2(Apolipoprotein A2) ELISA Kit
  • Mouse CX43(Connexin 43) ELISA Kit
  • Mouse APOA2(Apolipoprotein A2) ELISA Kit
  • Rat CX43(Connexin 43) ELISA Kit
  • Rat APOA2(Apolipoprotein A2) ELISA Kit
  • Chicken MMP13(Matrix Metalloproteinase 13) ELISA Kit
  • Mouse LAMa1(Laminin Alpha 1) ELISA Kit
  • Mouse FGFR1(Fibroblast Growth Factor Receptor 1) ELISA Kit
  • Human PLAA(Phospholipase A2 Activating Protein) ELISA Kit
  • Mouse EGR1(Early Growth Response Protein 1) ELISA Kit
  • Rat Alk-Smase(Alkaline Sphingomyelinase) ELISA Kit
  • Human NRP1(Neuropilin 1) ELISA Kit
  • Mouse Alk-Smase(Alkaline Sphingomyelinase) ELISA Kit
  • Human NRP2(Neuropilin 2) ELISA Kit
  • Human Alk-Smase(Alkaline Sphingomyelinase) ELISA Kit
  • Human XDH(Xanthine Dehydrogenase) ELISA Kit
  • Rat CCK(Cholecystokinin) ELISA Kit
  • Mouse HCII(Heparin Cofactor II) ELISA Kit
  • Mouse CCK(Cholecystokinin) ELISA Kit
  • Rat HCII(Heparin Cofactor II) ELISA Kit
  • Human CCK(Cholecystokinin) ELISA Kit
  • Rabbit HCII(Heparin Cofactor II) ELISA Kit
  • Human BMP7(Bone Morphogenetic Protein 7) ELISA Kit
  • Human GAL2(Galectin 2) ELISA Kit
  • Rat BMP7(Bone Morphogenetic Protein 7) ELISA Kit
  • Human GAL4(Galectin 4) ELISA Kit
  • Mouse BMP7(Bone Morphogenetic Protein 7) ELISA Kit
  • Mouse IL8Ra(Interleukin 8 Receptor Alpha) ELISA Kit
  • Human LFA3(Lymphocyte Function Associated Antigen 3) ELISA Kit
  • Mouse CXCR4(Chemokine C-X-C-Motif Receptor 4) ELISA Kit
  • Human ISR(Insulin Receptor) ELISA Kit
  • Human ARO(Aromatase) ELISA Kit
  • Rat ISR(Insulin Receptor) ELISA Kit
  • Human GAL8(Galectin 8) ELISA Kit
  • Human TRH(Thyrotropin Releasing Hormone) ELISA Kit
  • Mouse GAL8(Galectin 8) ELISA Kit
  • Mouse TRH(Thyrotropin Releasing Hormone) ELISA Kit
  • Human DCX(Doublecortin) ELISA Kit
  • Human NOS2(Nitric Oxide Synthase 2, Inducible) ELISA Kit
  • Human COL3a1(Collagen Type III Alpha 1) ELISA Kit
  • Rat INHbA(Inhibin Beta A) ELISA Kit
  • Mouse GAL12(Galectin 12) ELISA Kit
  • Mouse TPPP(Tubulin Polymerization Promoting Protein) ELISA Kit
  • Mouse GAL1(Galectin 1) ELISA Kit
  • Human RANkL(Receptor Activator Of Nuclear Factor Kappa B Ligand) ELISA Kit
  • Human MMP15(Matrix Metalloproteinase 15) ELISA Kit
  • Rat RANkL(Receptor Activator Of Nuclear Factor Kappa B Ligand) ELISA Kit
  • Mouse MMP15(Matrix Metalloproteinase 15) ELISA Kit
  • Mouse RANkL(Receptor Activator Of Nuclear Factor Kappa B Ligand) ELISA Kit
  • Human S100(S100 Calcium Binding Protein) ELISA Kit
  • Mouse GS(Gelsolin) ELISA Kit
  • Human KRT1(Keratin 1) ELISA Kit
  • Human ANGPTL1(Angiopoietin Like Protein 1) ELISA Kit
  • Human IDE(Insulin Degrading Enzyme) ELISA Kit
  • Rat ENA78(Epithelial Neutrophil Activating Peptide 78) ELISA Kit
  • Human LACRT(Lacritin) ELISA Kit
  • Mouse ENA78(Epithelial Neutrophil Activating Peptide 78) ELISA Kit
  • Human DCD(Dermcidin) ELISA Kit
  • Rat IP10(Interferon Gamma Induced Protein 10kDa) ELISA Kit
  • Mouse NPHN(Nephrin) ELISA Kit
  • Human Des(Desmin) ELISA Kit
  • Rat GDH(Glutamate Dehydrogenase 1) ELISA Kit
  • Rat Des(Desmin) ELISA Kit
  • Rabbit CTGF(Connective Tissue Growth Factor) ELISA Kit
  • Mouse Des(Desmin) ELISA Kit
  • Human TFR(Transferrin Receptor) ELISA Kit
  • Human ACTN2(Actinin Alpha 2) ELISA Kit
  • Chicken BMP2(Bone Morphogenetic Protein 2) ELISA Kit
  • Mouse ADCYAP1(Adenylate Cyclase Activating Polypeptide 1, Pituitary) ELISA Kit
  • Rabbit BMP2(Bone Morphogenetic Protein 2) ELISA Kit
  • Mouse EGFR2(Epidermal Growth Factor Receptor 2) ELISA Kit
  • Chicken BMP4(Bone Morphogenetic Protein 4) ELISA Kit
  • Human MASP1(Mannose Associated Serine Protease 1) ELISA Kit
  • Rabbit BMP4(Bone Morphogenetic Protein 4) ELISA Kit
  • Mouse IL33(Interleukin 33) ELISA Kit
  • Mouse S100(S100 Calcium Binding Protein) ELISA Kit
  • Human CSE(Cystathionine Gamma Lyase) ELISA Kit
  • Rat S100(S100 Calcium Binding Protein) ELISA Kit
  • Mouse IDE(Insulin Degrading Enzyme) ELISA Kit
  • Mouse MUC1(Mucin 1) ELISA Kit
  • Human ProIAPP(Proislet Amyloid Polypeptide) ELISA Kit
  • Rat MUC1(Mucin 1) ELISA Kit
  • Mouse TLR4(Toll Like Receptor 4) ELISA Kit
  • Chicken CNTF(Ciliary Neurotrophic Factor) ELISA Kit
  • Mouse TLR2(Toll Like Receptor 2) ELISA Kit
  • Rabbit CNTF(Ciliary Neurotrophic Factor) ELISA Kit
  • Human ALK1(Activin Receptor Like Kinase 1) ELISA Kit
  • Rabbit IL8Ra(Interleukin 8 Receptor Alpha) ELISA Kit
  • Human CDHH(Cadherin, Heart) ELISA Kit
  • Rat IL8Ra(Interleukin 8 Receptor Alpha) ELISA Kit
  • Human FCN3(Ficolin 3) ELISA Kit
  • Mouse GZMM(Granzyme M) ELISA Kit
  • Human GP6(Glycoprotein VI, Platelet) ELISA Kit
  • Chicken FGF1(Fibroblast Growth Factor 1, Acidic) ELISA Kit
  • Rat CTXII(Cross Linked C-Telopeptide Of Type II Collagen) ELISA Kit
  • Mouse F5(Coagulation Factor V) ELISA Kit
  • Human FCN2(Ficolin 2) ELISA Kit
  • Human CD4(Cluster Of Differentiation 4) ELISA Kit
  • Human AGC(Aggrecan) ELISA Kit
  • Mouse TPS(Tryptase) ELISA Kit
  • Human PUMA(p53 Upregulated Modulator Of Apoptosis) ELISA Kit
  • Human CCR2(Chemokine C-C-Motif Receptor 2) ELISA Kit
  • Human PKP1(Plakophilin 1) ELISA Kit
  • Rat ERb(Estrogen Receptor Beta) ELISA Kit
  • Human Smad4(Mothers Against Decapentaplegic Homolog 4) ELISA Kit
  • Mouse ERa(Estrogen Receptor Alpha) ELISA Kit
  • Human ANGPTL2(Angiopoietin Like Protein 2) ELISA Kit
  • Mouse AR(Androgen Receptor) ELISA Kit
  • Human DEFa5(Defensin Alpha 5, Paneth Cell Specific) ELISA Kit
  • Human RANk(Receptor Activator Of Nuclear Factor Kappa B) ELISA Kit
  • Human FPR2(Formyl Peptide Receptor 2) ELISA Kit
  • Human VLDL(Very Low Density Lipoprotein) ELISA Kit
  • Human Btk(Bruton’S Tyrosine Kinase) ELISA Kit
  • Chicken FGF4(Fibroblast Growth Factor 4) ELISA Kit
  • Rat PTGS2(Prostaglandin Endoperoxide Synthase 2) ELISA Kit
  • Chicken FGF9(Fibroblast Growth Factor 9) ELISA Kit
  • Human GAPDH(Glyceraldehyde-3-Phosphate Dehydrogenase) ELISA Kit
  • Human ALAD(Aminolevulinate Delta Dehydratase) ELISA Kit
  • Rat ALT(Alanine Aminotransferase) ELISA Kit
  • Human HSPA5(Heat Shock 70kDa Protein 5) ELISA Kit
  • Human CTSS(Cathepsin S) ELISA Kit
  • Human FGF3(Fibroblast Growth Factor 3) ELISA Kit
  • Human IL32(Interleukin 32) ELISA Kit
  • Mouse SNCa(Synuclein Alpha) ELISA Kit
  • Human LRG1(Leucine Rich Alpha-2-Glycoprotein 1) ELISA Kit
  • Mouse Pgp(Permeability Glycoprotein) ELISA Kit
  • Human TNX(Tenascin X) ELISA Kit
  • Human PROM1(Prominin 1) ELISA Kit
  • Mouse GPX1(Glutathione Peroxidase 1) ELISA Kit
  • Mouse C5(Complement Component 5) ELISA Kit
  • Mouse ALPL(Alkaline Phosphatase, Liver/Bone/Kidney) ELISA Kit
  • Mouse CTSS(Cathepsin S) ELISA Kit
  • Human SDC4(Syndecan 4) ELISA Kit
  • Human OSCAR(Osteoclast Associated Receptor) ELISA Kit
  • Human TFPI2(Tissue Factor Pathway Inhibitor 2) ELISA Kit
  • Mouse APC(Activated Protein C) ELISA Kit
  • Human IgD(Immunoglobulin D) ELISA Kit
  • Human CD24(Cluster Of Differentiation 24) ELISA Kit
  • Rat CKMB(Creatine Kinase MB Isoenzyme) ELISA Kit
  • Mouse IL19(Interleukin 19) ELISA Kit
  • Mouse a1AT(Alpha-1-Antitrypsin) ELISA Kit
  • Human HAase(Hyaluronidase) ELISA Kit
  • Mouse NRG1(Neuregulin 1) ELISA Kit
  • Human SIGLEC1(Sialic Acid Binding Ig Like Lectin 1) ELISA Kit
  • Human ANXA2(Annexin A2) ELISA Kit
  • Mouse MMP12(Matrix Metalloproteinase 12) ELISA Kit
  • Human EREG(Epiregulin) ELISA Kit
  • Mouse SPD(Surfactant Associated Protein D) ELISA Kit
  • Human ACR(Acrosin) ELISA Kit
  • Human CR1(Complement Receptor 1, Erythrocyte) ELISA Kit
  • Mouse TGFb3(Transforming Growth Factor Beta 3) ELISA Kit
  • Human EMMPRIN(Extracellular Matrix Metalloproteinase Inducer) ELISA Kit
  • Mouse TLR7(Toll Like Receptor 7) ELISA Kit
  • Human ADIPOR2(Adiponectin Receptor 2) ELISA Kit
  • Human TLR7(Toll Like Receptor 7) ELISA Kit
  • Rabbit NT-ProBNP(N-Terminal Pro-Brain Natriuretic Peptide) ELISA Kit
  • Human IL17B(Interleukin 17B) ELISA Kit
  • Human HDAC2(Histone Deacetylase 2) ELISA Kit
  • Rat PDHa(Pyruvate Dehydrogenase Alpha) ELISA Kit
  • Human AngIII(Angiotensin III) ELISA Kit
  • Human GSTa2(Glutathione S Transferase Alpha 2) ELISA Kit
  • Human PVRL4(Poliovirus Receptor Related Protein 4) ELISA Kit
  • Mouse MK(Midkine) ELISA Kit
  • Human Slit1(Slit Homolog 1) ELISA Kit
  • Mouse GT(Gastrin) ELISA Kit
  • Human PCIII(Procollagen III) ELISA Kit
  • Human CD34(Cluster Of Differentiation 34) ELISA Kit
  • Human OXTR(Oxytocin Receptor) ELISA Kit
  • Mouse CD34(Cluster Of Differentiation 34) ELISA Kit
  • Human HSF2(Heat Shock Transcription Factor 2) ELISA Kit
  • Human SOD1(Superoxide Dismutase 1, Soluble) ELISA Kit
  • Human GSTo1(Glutathione S Transferase Omega 1) ELISA Kit
  • Human DNM1(Dynamin 1) ELISA Kit
  • Human ASAH1(N-Acylsphingosine Amidohydrolase 1) ELISA Kit
  • Human DEFb1(Defensin Beta 1) ELISA Kit
  • Human LOR(Loricrin) ELISA Kit
  • Mouse LDL(Low Density Lipoprotein) ELISA Kit
  • Human PSAP(Prosaposin) ELISA Kit
  • Mouse HDL(High Density Lipoprotein) ELISA Kit
  • Rat VEGF121(Vascular Endothelial Growth Factor 121) ELISA Kit
  • Mouse CAPN1(Calpain 1, Large Subunit) ELISA Kit
  • Cattle RETN(Resistin) ELISA Kit
  • Mouse PLA2G2D(Phospholipase A2, Group IID) ELISA Kit
  • Mouse TBG(Thyroxine Binding Globulin) ELISA Kit
  • Human SDC1(Syndecan 1) ELISA Kit
  • Rat Slit2(Slit Homolog 2) ELISA Kit
  • Human APOD(Apolipoprotein D) ELISA Kit
  • Human CFTR(Cystic Fibrosis Transmembrane Conductance Regulator) ELISA Kit
  • Human C5(Complement Component 5) ELISA Kit
  • Human HSPG2(Heparan Sulfate Proteoglycan 2) ELISA Kit
  • Human ADAMTS1(A Disintegrin And Metalloproteinase With Thrombospondin 1) ELISA Kit
  • Human PDGFD(Platelet Derived Growth Factor D) ELISA Kit
  • Human C8g(Complement Component 8g) ELISA Kit
  • Human CTSC(Cathepsin C) ELISA Kit
  • Human ADAMTS7(A Disintegrin And Metalloproteinase With Thrombospondin 7) ELISA Kit
  • Human COL6(Collagen Type VI) ELISA Kit
  • Human PROS(Protein S) ELISA Kit
  • Rat SOX2(Sex Determining Region Y Box Protein 2) ELISA Kit
  • Human PEDF(Pigment Epithelium Derived Factor) ELISA Kit
  • Rat C4a(Complement Component 4a) ELISA Kit
  • Chicken LEP(Leptin) ELISA Kit
  • Human CCR3(Chemokine C-C-Motif Receptor 3) ELISA Kit
  • Human MMP28(Matrix Metalloproteinase 28) ELISA Kit
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  • Human TNC(Tenascin C) ELISA Kit
  • Mouse AGC(Aggrecan) ELISA Kit
  • Mouse ANXA2(Annexin A2) ELISA Kit
  • Human ERb(Estrogen Receptor Beta) ELISA Kit
  • Human IL33(Interleukin 33) ELISA Kit
  • Rat PON1(Paraoxonase 1) ELISA Kit
  • Human MAPt(Microtubule Associated Protein Tau) ELISA Kit
  • Human LRP2(Low Density Lipoprotein Receptor Related Protein 2) ELISA Kit
  • Human tPK1(Tau-Protein Kinase 1) ELISA Kit
  • Mouse GAS6(Growth Arrest Specific Protein 6) ELISA Kit
  • Mouse MBL(Mannose Binding Lectin) ELISA Kit
  • Chicken ADP(Adiponectin) ELISA Kit
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  • Human EFNA1(Ephrin A1) ELISA Kit
  • Human TLR5(Toll Like Receptor 5) ELISA Kit
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  • General LPS(Lipopolysaccharide) ELISA Kit
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  • Mouse MAPt(Microtubule Associated Protein Tau) ELISA Kit
  • Chicken IL12B(Interleukin 12B) ELISA Kit
  • Mouse HJV(Hemojuvelin) ELISA Kit
  • Human IL35(Interleukin 35) ELISA Kit
  • Human COL2a1(Collagen Type II Alpha 1) ELISA Kit
  • Human PCII(Procollagen II) ELISA Kit
  • Mouse ADH1(Alcohol Dehydrogenase 1) ELISA Kit
  • Mouse FOXP3(Forkhead Box Protein P3) ELISA Kit
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  • Human IL22(Interleukin 22) ELISA Kit
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  • Human APOM(Apolipoprotein M) ELISA Kit
  • Rat MUC5AC(Mucin 5 Subtype AC) ELISA Kit
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  • Human AFM(Afamin) ELISA Kit
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energy crisis

The vital hormone 20-hydroxyecdysone controls ATP production by upregulating binding of Trehalase 1 with ATP synthase subunit α in Helicoverpa armigera

February 22, 2022 by Yamada
Trehalose is the major “blood sugar” of insects and it plays a crucial role in energy supply and as a stress protectant. The hydrolysis of trehalose occurs only under the enzymatic control of trehalase (Treh), which plays important roles in growth and development, energy supply, chitin biosynthesis, and abiotic stress responses. Previous reports have revealed that the vital hormone 20-hydroxyecdysone (20E) regulates Treh, but the detailed mechanism underlying 20E regulating Treh remains unclear. In this study, we investigated the function of HaTreh1 in Helicoverpa armigera larvae. Results showed that the transcript levels and enzymatic activity of HaTreh1 were elevated during molting and metamorphosis stages in the epidermis, midgut, and fat body, and that 20E upregulated the transcript levels of HaTreh1 through the classical nuclear receptor complex EcR-B1/USP1. HaTreh1 is a mitochondria protein.
We also found that knockdown of HaTreh1 in the fifth- or sixth- instar larvae resulted in weight loss and increased mortality. Yeast two-hybrid, Co-IP, and GST pull-down experiments demonstrated that HaTreh1 bound with ATP synthase subunit alpha (HaATPs-α) and that this binding increased under 20E treatment. In addition, 20E enhanced the transcript level of HaATPs-α and ATP content. Finally, the knockdown of HaTreh1 or HaATPs-α decreased the induction effect of 20E on ATP content. Altogether, these findings demonstrate that 20E controls ATP production by up-regulating the binding of HaTreh1 to HaATPs-α in H. armigera.

Ecdysone and 20-hydroxyecdysone are not required to activate glycolytic gene expression in Drosophila melanogaster embryos

Many of the Drosophila enzymes involved in carbohydrate metabolism are coordinately up-regulated approximately midway through embryogenesis. Previous studies have demonstrated that this metabolic transition is controlled by the Drosophila Estrogen-Related Receptor (dERR), which is stabilized and activated immediately prior to onset of glycolytic gene expression. The mechanisms that promote dERR activity, however, are poorly understood and other transcriptional regulators could control this metabolic transition, independent of dERR.
In this regard, the steroid hormone 20-hydroxyecdysone (20E) represents an intriguing candidate for regulating glycolytic gene expression in embryos – not only does the embryonic 20E pulse immediately precede transcriptional up-regulation of glycolytic metabolism, but 20E is also known to promote Lactate dehydrogenase gene expression. Here I test the hypothesis that embryonic 20E signaling is required to activate glycolytic gene expression. Using developmental northern blots, I demonstrate that the transcriptional up-regulation of glycolytic genes during embryogenesis still occurs in shadow mutants, which are unable to synthesize either ecdysone or 20E. My finding indicates that ecdysone and 20E signaling are not required for this mid-embryonic metabolic transition.

20-Hydroxyecdysone activates the protective arm of the RAAS via Mas receptor

20-Hydroxyecdysone (20E) is a steroid hormone that plays a key role in insect development through nuclear ecdysteroid receptors (EcR/RXR complex) and at least one membrane GPCR receptor (DopEcR). It also displays numerous pharmacological effects in mammals, where its mechanism of action is still debated, involving either an unidentified GPCR or the estrogen ERβ receptor. The goal of this study was to better understand 20E mechanism of action in mammals. A mouse myoblast cell line (C2C12) and the gene expression of myostatin (a negative regulator of muscle growth) was used as a reporter system of anabolic activity. Experiments using protein-bound 20E established the involvement of a membrane receptor. 20E-like effects were also observed with angiotensin-(1-7), the endogenous ligand of Mas.
Additionally, the effect on myostatin gene expression was abolished by Mas receptor knock-down using small interfering RNA (siRNA) or pharmacological inhibitors. 17β-Estradiol (E2) also inhibited myostatin gene expression, but protein-bound E2 was inactive, and E2 activity was not abolished by angiotensin-(1-7) antagonists. A mechanism involving cooperation between the Mas receptor and a membrane-bound palmitoylated estrogen receptor is proposed. The possibility to activate the Mas receptor with a safe steroid molecule is consistent with the pleiotropic pharmacological effects of ecdysteroids in mammals and, indeed, the proposed mechanism may explain the close similarity between angiotensin-(1-7)’s and 20E’s effects. Our findings open up many possible therapeutic developments involving stimulation of the protective arm of the renin-angiotensin-aldosterone system (RAAS) with 20E.

Identification and Functional Analysis of G Protein-Coupled Receptors in 20-Hydroxyecdysone Signaling From the Helicoverpa armigera Genome

G protein-coupled receptors (GPCRs) are the largest family of membrane receptors in animals and humans, which transmit various signals from the extracellular environment into cells. Studies have reported that several GPCRs transmit the same signal; however, the mechanism is unclear. In the present study, we identified all 122 classical GPCRs from the genome of Helicoverpa armigera, a lepidopteran pest species. Twenty-four GPCRs were identified as upregulated at the metamorphic stage by comparing the transcriptomes of the midgut at the metamorphic and feeding stages.Nine of them were confirmed to be upregulated at the metamorphic stage. RNA interference in larvae revealed the prolactin-releasing peptide receptor (PRRPR), smoothened (SMO), adipokinetic hormone receptor (AKHR), and 5-hydroxytryptamine receptor (HTR) are involved in steroid hormone 20-hydroxyecdysone (20E)-promoted pupation. Frizzled 7 (FZD7) is involved in growth, while tachykinin-like peptides receptor 86C (TKR86C) had no effect on growth and pupation.
Via these GPCRs, 20E regulated the expression of different genes, respectively, including Pten (encoding phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase), FoxO (encoding forkhead box O), BrZ7 (encoding broad isoform Z7), Kr-h1 (encoding Krüppel homolog 1), Wnt (encoding Wingless/Integrated) and cMyc, with hormone receptor 3 (HHR3) as their common regulating target. PRRPR was identified as a new 20E cell membrane receptor using a binding assay. These data suggested that 20E, via different GPCRs, regulates different gene expression to integrate growth and development.

20-Hydroxyecdysone, 90%

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20-Hydroxyecdysone, 97%

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20-Hydroxyecdysone, 97%

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20-hydroxyecdysone 3-acetate

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DetectX® 20-Hydroxyecdysone Conjugate, 3ML

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20-Hydroxyecdysone EIA Kit (One Plate)

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20-Hydroxyecdysone EIA Kit (Five Plate)

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Activation of the ROS/CncC and 20-Hydroxyecdysone Signaling Pathways Is Associated with Xanthotoxin-Induced Tolerance to λ-Cyhalothrin in Spodoptera litura

Adaptation to phytochemicals in herbivorous insects can influence tolerance to insecticides. However, it is unclear how insects use phytochemicals as cues to activate their metabolic detoxification systems. In this study, we found that dietary exposure to xanthotoxin enhanced tolerance of Spodoptera litura larvae to λ-cyhalothrin. Xanthotoxin ingestion significantly elevated the mRNA levels of 35 detoxification genes as well as the transcription factors Cap ‘n’ collar isoform-C (CncC) and its binding factor small muscle aponeurosis fibromatosis isoform-K (MafK). Additionally, xanthotoxin exposure increased the levels of reactive oxygen species (ROS), while ROS inhibitor N-acetylcysteine (NAC) treatment blocked xanthotoxin-induced expression of CncC, MafK, and detoxification genes and also prevented xanthotoxin-enhanced larval tolerance to λ-cyhalothrin. The 20-hydroxyecdysone (20E) signaling pathway was effectively activated by xanthotoxin, while blocking of 20E signaling transduction prevented xanthotoxin-enhanced larval tolerance to λ-cyhalothrin.
Application of 20E induced the expression of multiple xanthotoxin-induced detoxification genes and enhanced λ-cyhalothrin tolerance in S. litura. NAC treatment blocked xanthotoxin-induced 20E synthesis, while the CncC agonist curcumin activated the 20E signaling pathway. These results indicate that the ROS/CncC pathway controls the induction of metabolic detoxification upon exposure to xanthotoxin, at least in part, through its regulation of the 20E signaling pathway.
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