Ruxolitinib was found to fully inhibit lipopolysaccharide (LPS)-induced CRP secretion and mRNA expression, at concentrations (IC50 = 12.9 nM) achievable in human blood. It similarly repressed CRP up-regulation due to several Toll-like receptor agonists or pro-inflammatory cytokines [interleukin (IL) 1β, IL6 and tumour necrosis factor α] and counteracted LPS-mediated induction of serum amyloid A, fibrinogen, haptoglobin and serpin. Ruxolitinib was additionally found to block the activation of the IL6/JAK/signal transducer and activator of transcription (STAT) pathway triggered by LPS and whose inhibition by the neutralizing anti-IL6 receptor antibody tocilizumab prevented CRP induction.Ruxolitinib can potently repress induction of CRP in inflammatory human hepatocytes, most likely through targeting the IL6/JAK/STAT signalling cascade. Hepatic production of acute-phase proteins during liver inflammation may, therefore, constitute a target for ruxolitinib.
Nanomolar aluminum induces expression of the inflammatory systemic biomarker C–reactive protein (CRP) in human brain microvessel endothelial cells (hBMECs).
High sensitivity C–reactive protein (Hs-CRP) remains highly stable in long-term archived human serum.
C–reactive protein (CRP) induces chemokine secretion via CD11b/ICAM-1 interaction in human adherent monocytes.
Human C Reactive Protein (CRP) Protein |
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20-abx168571 | Abbexa |
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Human C Reactive Protein (CRP) Protein |
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20-abx065612 | Abbexa |
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Human C Reactive Protein (CRP) CLIA Kit |
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20-abx490698 | Abbexa |
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Human C Reactive Protein (CRP)CLIA Kit |
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SCA821Hu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | 6777.36 EUR |
Human C Reactive Protein (CRP)CLIA Kit |
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SCA821Hu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | 663.31 EUR |
Human C Reactive Protein (CRP)CLIA Kit |
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SCA821Hu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | 896.16 EUR |
Human C Reactive Protein (CRP)CLIA Kit |
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SCA821Hu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | 3672.72 EUR |
Human C Reactive Protein (CRP) CLIA Kit |
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4-SCA821Hu | Cloud-Clone |
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Human C Reactive Protein (CRP) ELISA Kit |
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20-abx151187 | Abbexa |
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Human C Reactive Protein (CRP) ELISA Kit |
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DLR-CRP-Hu-48T | DL Develop | 48T | 462 EUR |
Human C Reactive Protein (CRP) ELISA Kit |
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DLR-CRP-Hu-96T | DL Develop | 96T | 590.4 EUR |
Human C Reactive Protein (CRP) ELISA Kit |
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LF-EK60021 | Abfrontier | 1×96T | 814.8 EUR |
Human C- reactive protein, CRP ELISA KIT |
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ELI-02800h | Lifescience Market | 96 Tests | 988.8 EUR |
Human C Reactive Protein (CRP) ELISA Kit |
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RDR-CRP-Hu-48Tests | Reddot Biotech | 48 Tests | 465.6 EUR |
Human C Reactive Protein (CRP) ELISA Kit |
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RDR-CRP-Hu-96Tests | Reddot Biotech | 96 Tests | 639.6 EUR |
Human C Reactive Protein (CRP) ELISA Kit |
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RD-CRP-Hu-48Tests | Reddot Biotech | 48 Tests | 446.4 EUR |
Human C Reactive Protein (CRP) ELISA Kit |
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RD-CRP-Hu-96Tests | Reddot Biotech | 96 Tests | 612 EUR |
Human C Reactive Protein (CRP) ELISA Kit |
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SEA821Hu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | 3753.58 EUR |
Human C Reactive Protein (CRP) ELISA Kit |
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SEA821Hu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | 414.3 EUR |
Human C Reactive Protein (CRP) ELISA Kit |
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SEA821Hu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | 540.42 EUR |
Human C Reactive Protein (CRP) ELISA Kit |
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SEA821Hu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | 2071.9 EUR |
Human C Reactive Protein (CRP) ELISA Kit |
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4-SEA821Hu | Cloud-Clone |
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Active C Reactive Protein (CRP) |
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4-APA821Hu01 | Cloud-Clone |
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Native C Reactive Protein (CRP) |
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4-NPA821Hu02 | Cloud-Clone |
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C Reactive Protein (CRP) Antibody |
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20-abx104766 | Abbexa |
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C Reactive Protein (CRP) Antibody |
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20-abx104840 | Abbexa |
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