Ruxolitinib was found to fully inhibit lipopolysaccharide (LPS)-induced CRP secretion and mRNA expression, at concentrations (IC50 = 12.9 nM) achievable in human blood. It similarly repressed CRP up-regulation due to several Toll-like receptor agonists or pro-inflammatory cytokines [interleukin (IL) 1β, IL6 and tumour necrosis factor α] and counteracted LPS-mediated induction of serum amyloid A, fibrinogen, haptoglobin and serpin. Ruxolitinib was additionally found to block the activation of the IL6/JAK/signal transducer and activator of transcription (STAT) pathway triggered by LPS and whose inhibition by the neutralizing anti-IL6 receptor antibody tocilizumab prevented CRP induction.Ruxolitinib can potently repress induction of CRP in inflammatory human hepatocytes, most likely through targeting the IL6/JAK/STAT signalling cascade. Hepatic production of acute-phase proteins during liver inflammation may, therefore, constitute a target for ruxolitinib.
Nanomolar aluminum induces expression of the inflammatory systemic biomarker C–reactive protein (CRP) in human brain microvessel endothelial cells (hBMECs).
High sensitivity C–reactive protein (Hs-CRP) remains highly stable in long-term archived human serum.
C–reactive protein (CRP) induces chemokine secretion via CD11b/ICAM-1 interaction in human adherent monocytes.
Human C Reactive Protein (CRP) ELISA Kit |
|||
DLR-CRP-Hu-48T | DL Develop | 48T | 462 EUR |
Human C Reactive Protein (CRP) ELISA Kit |
|||
DLR-CRP-Hu-96T | DL Develop | 96T | 590.4 EUR |
Human C Reactive Protein (CRP) ELISA Kit |
|||
RD-CRP-Hu-48Tests | Reddot Biotech | 48 Tests | 446.4 EUR |
Human C Reactive Protein (CRP) ELISA Kit |
|||
RD-CRP-Hu-96Tests | Reddot Biotech | 96 Tests | 612 EUR |
Human C Reactive Protein (CRP) ELISA Kit |
|||
RDR-CRP-Hu-48Tests | Reddot Biotech | 48 Tests | 465.6 EUR |
Human C Reactive Protein (CRP) ELISA Kit |
|||
RDR-CRP-Hu-96Tests | Reddot Biotech | 96 Tests | 639.6 EUR |
Bovine C Reactive Protein (CRP) ELISA Kit |
|||
DLR-CRP-b-48T | DL Develop | 48T | 656.4 EUR |
Bovine C Reactive Protein (CRP) ELISA Kit |
|||
DLR-CRP-b-96T | DL Develop | 96T | 858 EUR |
Chicken C Reactive Protein (CRP) ELISA Kit |
|||
DLR-CRP-Ch-48T | DL Develop | 48T | 609.6 EUR |
Chicken C Reactive Protein (CRP) ELISA Kit |
|||
DLR-CRP-Ch-96T | DL Develop | 96T | 793.2 EUR |
Mouse C Reactive Protein (CRP) ELISA Kit |
|||
DLR-CRP-Mu-48T | DL Develop | 48T | 586.8 EUR |
Mouse C Reactive Protein (CRP) ELISA Kit |
|||
DLR-CRP-Mu-96T | DL Develop | 96T | 762 EUR |
Porcine C Reactive Protein (CRP) ELISA Kit |
|||
DLR-CRP-p-48T | DL Develop | 48T | 656.4 EUR |
Porcine C Reactive Protein (CRP) ELISA Kit |
|||
DLR-CRP-p-96T | DL Develop | 96T | 858 EUR |
Rat C Reactive Protein (CRP) ELISA Kit |
|||
DLR-CRP-Ra-48T | DL Develop | 48T | 511.2 EUR |
Rat C Reactive Protein (CRP) ELISA Kit |
|||
DLR-CRP-Ra-96T | DL Develop | 96T | 658.8 EUR |
Rabbit C Reactive Protein (CRP) ELISA Kit |
|||
DLR-CRP-Rb-48T | DL Develop | 48T | 609.6 EUR |
Rabbit C Reactive Protein (CRP) ELISA Kit |
|||
DLR-CRP-Rb-96T | DL Develop | 96T | 793.2 EUR |
Bovine C Reactive Protein (CRP) ELISA Kit |
|||
RD-CRP-b-48Tests | Reddot Biotech | 48 Tests | 666 EUR |
Bovine C Reactive Protein (CRP) ELISA Kit |
|||
RD-CRP-b-96Tests | Reddot Biotech | 96 Tests | 925.2 EUR |
Chicken C Reactive Protein (CRP) ELISA Kit |
|||
RD-CRP-Ch-48Tests | Reddot Biotech | 48 Tests | 613.2 EUR |
Chicken C Reactive Protein (CRP) ELISA Kit |
|||
RD-CRP-Ch-96Tests | Reddot Biotech | 96 Tests | 850.8 EUR |
Mouse C Reactive Protein (CRP) ELISA Kit |
|||
RD-CRP-Mu-48Tests | Reddot Biotech | 48 Tests | 586.8 EUR |
Mouse C Reactive Protein (CRP) ELISA Kit |
|||
RD-CRP-Mu-96Tests | Reddot Biotech | 96 Tests | 812.4 EUR |
Porcine C Reactive Protein (CRP) ELISA Kit |
|||
RD-CRP-p-48Tests | Reddot Biotech | 48 Tests | 666 EUR |
Porcine C Reactive Protein (CRP) ELISA Kit |
|||
RD-CRP-p-96Tests | Reddot Biotech | 96 Tests | 925.2 EUR |